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Modification of the production of se...

Fritz, Kay Louderback.

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Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones./
Author:	Fritz, Kay Louderback.
Description:	93 p.
Notes:	Adviser: A. Saari Csallany.
Contained By:	Dissertation Abstracts International67-07B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3225735
ISBN:	9780542793639

Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones.
Fritz, Kay Louderback.

Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones. - 93 p.

Adviser: A. Saari Csallany.

Thesis (Ph.D.)--University of Minnesota, 2006.

Lipid peroxidation (LP) has been related in the literature to a number of diseases including heart disease, cancer, diabetes, cataract, liver, neurodegenerative, and other diseases including aging. The following three experiments were conducted to better understand the relationship between certain dietary factors and LP in vivo. The first experiment was designed to determine if a diet high in stearic acid (SA) can decrease in vivo LP compared to a diet high in polyunsaturated fatty acids (PUFA). Feeding a fat high in SA, compared to soybean oil (SO), a high PUFA fat, to rats resulted in a decreased amount of secondary LP products (SLPP) excreted in the urine, indicating a lower level of LP in vivo. The high SA diet increased the serum resistance to oxidation in vivo compared to the high PUFA SO diet in rats. No significant differences were found in serum cholesterol levels between the SA and PUFA SO fed animals. The second experiment was designed to test whether human consumption of soy isoflavones (SI) will exert an antioxidant effect as detected by a decrease in the urinary excretion of SLPP. Results showed that dietary SI in women (1 to 2 mg per kg body weight per day) significantly decreased the urinary excretion of SLPP. These results indicate that there is an in vivo antioxidant action of SI in human subjects. The third experiment was conducted to identify in normal human urine 4-hydroxy-2-trans-hexenal (HHE), one of the highly reactive alpha,beta-unsaturated hydroxy aldehydes resulting from the in vivo LP of omega-3 fatty acids. High performance liquid chromatography and cochromatography in various polarity solvent systems with pure HHE standard was used for confirming the existence of HHE in human urine. Urinary HHE could be used as a non-invasive biomarker for the in vivo oxidative degradation of omega-3 fatty acids.

ISBN: 9780542793639Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones.
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035 $a (UMI)AAI3225735
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040 $a UMI $c UMI
100 1 $a Fritz, Kay Louderback. $3 1264976
245 1 0 $a Modification of the production of secondary lipid peroxidation products in vivo in humans and rats by dietary fat and soy isoflavones.
300 $a 93 p.
500 $a Adviser: A. Saari Csallany.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3712.
502 $a Thesis (Ph.D.)--University of Minnesota, 2006.
520 $a Lipid peroxidation (LP) has been related in the literature to a number of diseases including heart disease, cancer, diabetes, cataract, liver, neurodegenerative, and other diseases including aging. The following three experiments were conducted to better understand the relationship between certain dietary factors and LP in vivo. The first experiment was designed to determine if a diet high in stearic acid (SA) can decrease in vivo LP compared to a diet high in polyunsaturated fatty acids (PUFA). Feeding a fat high in SA, compared to soybean oil (SO), a high PUFA fat, to rats resulted in a decreased amount of secondary LP products (SLPP) excreted in the urine, indicating a lower level of LP in vivo. The high SA diet increased the serum resistance to oxidation in vivo compared to the high PUFA SO diet in rats. No significant differences were found in serum cholesterol levels between the SA and PUFA SO fed animals. The second experiment was designed to test whether human consumption of soy isoflavones (SI) will exert an antioxidant effect as detected by a decrease in the urinary excretion of SLPP. Results showed that dietary SI in women (1 to 2 mg per kg body weight per day) significantly decreased the urinary excretion of SLPP. These results indicate that there is an in vivo antioxidant action of SI in human subjects. The third experiment was conducted to identify in normal human urine 4-hydroxy-2-trans-hexenal (HHE), one of the highly reactive alpha,beta-unsaturated hydroxy aldehydes resulting from the in vivo LP of omega-3 fatty acids. High performance liquid chromatography and cochromatography in various polarity solvent systems with pure HHE standard was used for confirming the existence of HHE in human urine. Urinary HHE could be used as a non-invasive biomarker for the in vivo oxidative degradation of omega-3 fatty acids.
590 $a School code: 0130.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 $a University of Minnesota. $3 676231
773 0 $t Dissertation Abstracts International $g 67-07B.
790 $a 0130
790 1 0 $a Csallany, A. Saari, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3225735