東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Drug nanoparticle formation via flas...

Saad, Walid S.

Linked to FindBook

Google Book

Amazon

博客來

Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel./
Author:	Saad, Walid S.
Description:	198 p.
Notes:	Adviser: Robert Prudhomme.
Contained By:	Dissertation Abstracts International68-01B.
Subject:	Engineering, Chemical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3250037

Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel.
Saad, Walid S.

Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel. - 198 p.

Adviser: Robert Prudhomme.

Thesis (Ph.D.)--Princeton University, 2007.

This thesis provides a strategy for the formation of stable, controlled size nanoparticle formulations for the controlled release of drugs. The approach detailed in the dissertation involves two main steps. First, the drug of interest is linked to a low solubility molecule to produce a drug conjugate with lower water solubility than the original drug. The second step involves using a fast mixing technique termed Flash NanoPrecipitation, where an amphiphilic diblock copolymer and the drug conjugate are mixed at high velocity in a confined volume to afford nucleation and growth of the solutes and produce nanoparticles. This technique provides high drug contents, high loading efficiencies, controllable sizes, and control of the drug release rates from the nanoparticles through modification of the linker chemistries used to produce the drug conjugate.Subjects--Topical Terms:

1018531
Engineering, Chemical.

Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel.
LDR:03216nam 2200289 a 45 001 940332
005 20110518
008 110518s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3250037
035 $a AAI3250037
040 $a UMI $c UMI
100 1 $a Saad, Walid S. $3 1264458
245 1 0 $a Drug nanoparticle formation via flash nanoprecipitation: Conjugation to encapsulate and control the release of paclitaxel.
300 $a 198 p.
500 $a Adviser: Robert Prudhomme.
500 $a Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0461.
502 $a Thesis (Ph.D.)--Princeton University, 2007.
520 $a This thesis provides a strategy for the formation of stable, controlled size nanoparticle formulations for the controlled release of drugs. The approach detailed in the dissertation involves two main steps. First, the drug of interest is linked to a low solubility molecule to produce a drug conjugate with lower water solubility than the original drug. The second step involves using a fast mixing technique termed Flash NanoPrecipitation, where an amphiphilic diblock copolymer and the drug conjugate are mixed at high velocity in a confined volume to afford nucleation and growth of the solutes and produce nanoparticles. This technique provides high drug contents, high loading efficiencies, controllable sizes, and control of the drug release rates from the nanoparticles through modification of the linker chemistries used to produce the drug conjugate.
520 $a The study focused on the anticancer drug paclitaxel, which was conjugated to vitamin E succinate (VES) to produce a paclitaxel-VES conjugate, and was formulated into nanoparticles by Flash NanoPrecipitation using methoxy poly (ethylene glycol)-b-poly (epsilon-caprolactone) (mPEG-PCL) diblock copolymers. The produced nanoparticles were characterized for size by dynamic light scattering (DLS), and showed no change in size or cleavage of paclitaxel from the conjugate in DI water at 4°C for over two weeks. Particle sizes in the range of 53-287 nm were produced by changing the solute concentration in the particle formation process, or through modifying the molecular weight of added poly (epsilon-caprolactone) homopolymer.
520 $a Paclitaxel release from paclitaxel conjugate nanoparticles under various conditions of temperature in the range of 4-37°C, and pH of 5.5 to 8, resulted in paclitaxel release half-lives of over 30 days, and the kinetics were attributed mainly to the slower ester cleavage due to the neighboring group effect. The in vivo circulation of the nanoparticles was evaluated in mice, and resulted in plasma circulation half-lives of up to 18 hours, with a clear effect of the copolymer block composition on the nanoparticle circulation profile. The micellization of mPEG-PCL was evaluated using light scattering, and the relative effect of each block revealed in mixtures of water and tetrahydrofuran.
590 $a School code: 0181.
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0542
690 $a 0572
710 2 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 68-01B.
790 $a 0181
790 1 0 $a Prudhomme, Robert, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3250037