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Primary progressive aphasia: Perspec...

Sonty, Sreepadma Priya (Siri).

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Primary progressive aphasia: Perspectives from functional and structural neuroimaging.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Primary progressive aphasia: Perspectives from functional and structural neuroimaging./
Author:	Sonty, Sreepadma Priya (Siri).
Description:	246 p.
Notes:	Advisers: Darren R. Gitelman; M. Marsel Mesulam.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260548

Primary progressive aphasia: Perspectives from functional and structural neuroimaging.
Sonty, Sreepadma Priya (Siri).

Primary progressive aphasia: Perspectives from functional and structural neuroimaging. - 246 p.

Advisers: Darren R. Gitelman; M. Marsel Mesulam.

Thesis (Ph.D.)--Northwestern University, 2007.

Primary progressive aphasia (PPA) is a debilitating neurodegenerative syndrome that principally impairs the cognitive domain of language. Patients demonstrate deficits in a variety of language faculties including object naming (anomia), word finding, single word and sentence reading, speech comprehension, repetition, syntactic processing, and paraphasia. PPA has been associated with selective atrophy within the left hemisphere in the vicinity of the Sylvian fissure, the known location of neural systems supporting language function. This dissertation is a compilation of work examining the neural correlates of dysfunction within the language network in non-fluent PPA, using functional and structural magnetic resonance imaging (fMRI) in conjunction with single word processing tasks. This dissertation also employs dynamic causal modeling (DCM) for the investigation of inter-regional influences within the PPA language network, and voxel-based morphometry (VBM) to quantitatively characterize grey matter atrophy in PPA. The studies in this dissertation reveal behavioral dysfunction and altered functional neuroanatomy for phonological and lexico-semantic single word processing associated with significant left temporoparietal atrophy, and altered network interactions within the language network, specifically from posterior superior temporal lobe (Wernicke's area) to inferior frontal gyrus (Broca's area) in PPA. These disruptions impact both incidental and explicit lexico-semantic processing, and may underlie the myriad clinical language deficits observed in PPA.Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Primary progressive aphasia: Perspectives from functional and structural neuroimaging.
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035 $a (UMI)AAI3260548
035 $a AAI3260548
040 $a UMI $c UMI
100 1 $a Sonty, Sreepadma Priya (Siri). $3 1264053
245 1 0 $a Primary progressive aphasia: Perspectives from functional and structural neuroimaging.
300 $a 246 p.
500 $a Advisers: Darren R. Gitelman; M. Marsel Mesulam.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2126.
502 $a Thesis (Ph.D.)--Northwestern University, 2007.
520 $a Primary progressive aphasia (PPA) is a debilitating neurodegenerative syndrome that principally impairs the cognitive domain of language. Patients demonstrate deficits in a variety of language faculties including object naming (anomia), word finding, single word and sentence reading, speech comprehension, repetition, syntactic processing, and paraphasia. PPA has been associated with selective atrophy within the left hemisphere in the vicinity of the Sylvian fissure, the known location of neural systems supporting language function. This dissertation is a compilation of work examining the neural correlates of dysfunction within the language network in non-fluent PPA, using functional and structural magnetic resonance imaging (fMRI) in conjunction with single word processing tasks. This dissertation also employs dynamic causal modeling (DCM) for the investigation of inter-regional influences within the PPA language network, and voxel-based morphometry (VBM) to quantitatively characterize grey matter atrophy in PPA. The studies in this dissertation reveal behavioral dysfunction and altered functional neuroanatomy for phonological and lexico-semantic single word processing associated with significant left temporoparietal atrophy, and altered network interactions within the language network, specifically from posterior superior temporal lobe (Wernicke's area) to inferior frontal gyrus (Broca's area) in PPA. These disruptions impact both incidental and explicit lexico-semantic processing, and may underlie the myriad clinical language deficits observed in PPA.
590 $a School code: 0163.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Speech Pathology. $3 1018105
690 $a 0317
690 $a 0460
710 2 $a Northwestern University. $b Neuroscience Institute Graduate Program. $3 1023500
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0163
790 1 0 $a Gitelman, Darren R., $e advisor
790 1 0 $a Mesulam, M. Marsel, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260548