東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Multi-level regulation of cyclin D3 ...

Cooper, Anthony Byron.

Linked to FindBook

Google Book

Amazon

博客來

Multi-level regulation of cyclin D3 controls pre-B cell expansion.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Multi-level regulation of cyclin D3 controls pre-B cell expansion./
Author:	Cooper, Anthony Byron.
Description:	198 p.
Notes:	Adviser: Marcus R. Clark.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3252227

Multi-level regulation of cyclin D3 controls pre-B cell expansion.
Cooper, Anthony Byron.

Multi-level regulation of cyclin D3 controls pre-B cell expansion. - 198 p.

Adviser: Marcus R. Clark.

Thesis (Ph.D.)--The University of Chicago, 2007.

During hematopoiesis, stem cell proliferation is dependent upon expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Analysis of Ccnd1-/-, Ccnd2-/-, Ccnd3-/- and Ccnd2-/-Ccnd3-/- mice revealed that cyclin D3 is uniquely required for the proliferative expansion of pre-B cells. Transcription of Ccnd3 is activated before the pro-B stage of development in a process dependent on expression of the common gamma chain of cytokine receptors. In contrast, expression of the pre-BCR and the activation of downstream signaling pathways involving Src and PI3K, but not BLNK, prevent proteasome-mediated cyclin D3 degradation. Additionally signaling through the IL-7 receptor regulates cyclin D3 expression via a mechanism independent of protein stability or transcription, possibly through translational regulation. Cyclin D3 plays a key role in B cell development by integrating cytokine and pre-BCR dependent signals at the appropriate developmental stage in order to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.Subjects--Topical Terms:

1017686
Biology, Cell.

Multi-level regulation of cyclin D3 controls pre-B cell expansion.
LDR:01995nam 2200265 a 45 001 939222
005 20110512
008 110512s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3252227
035 $a AAI3252227
040 $a UMI $c UMI
100 1 $a Cooper, Anthony Byron. $3 1263217
245 1 0 $a Multi-level regulation of cyclin D3 controls pre-B cell expansion.
300 $a 198 p.
500 $a Adviser: Marcus R. Clark.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0875.
502 $a Thesis (Ph.D.)--The University of Chicago, 2007.
520 $a During hematopoiesis, stem cell proliferation is dependent upon expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Analysis of Ccnd1-/-, Ccnd2-/-, Ccnd3-/- and Ccnd2-/-Ccnd3-/- mice revealed that cyclin D3 is uniquely required for the proliferative expansion of pre-B cells. Transcription of Ccnd3 is activated before the pro-B stage of development in a process dependent on expression of the common gamma chain of cytokine receptors. In contrast, expression of the pre-BCR and the activation of downstream signaling pathways involving Src and PI3K, but not BLNK, prevent proteasome-mediated cyclin D3 degradation. Additionally signaling through the IL-7 receptor regulates cyclin D3 expression via a mechanism independent of protein stability or transcription, possibly through translational regulation. Cyclin D3 plays a key role in B cell development by integrating cytokine and pre-BCR dependent signals at the appropriate developmental stage in order to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.
590 $a School code: 0330.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0379
690 $a 0982
710 2 $a The University of Chicago. $3 1017389
773 0 $t Dissertation Abstracts International $g 68-02B.
790 $a 0330
790 1 0 $a Clark, Marcus R., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3252227