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Genetic and cellular interactions th...

Gosse, Nathan J.

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Genetic and cellular interactions that shape the zebrafish retinotectal projection.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genetic and cellular interactions that shape the zebrafish retinotectal projection./
Author:	Gosse, Nathan J.
Description:	75 p.
Notes:	Adviser: Herwig Baier.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289323
ISBN:	9780549333258

Genetic and cellular interactions that shape the zebrafish retinotectal projection.
Gosse, Nathan J.

Genetic and cellular interactions that shape the zebrafish retinotectal projection. - 75 p.

Adviser: Herwig Baier.

Thesis (Ph.D.)--University of California, San Francisco, 2008.

The retinotectal projection has long served as an experimentally accessible model for the study of topographic map formation and function. Retinal ganglion cells (RGCs) project to their midbrain target, the optic tectum, such that neighbor relationships are preserved between pre- and postsynaptic cells.

ISBN: 9780549333258Subjects--Topical Terms:

1017730
Biology, Genetics.

Genetic and cellular interactions that shape the zebrafish retinotectal projection.
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020 $a 9780549333258
035 $a (UMI)AAI3289323
035 $a AAI3289323
040 $a UMI $c UMI
100 1 $a Gosse, Nathan J. $3 1263087
245 1 0 $a Genetic and cellular interactions that shape the zebrafish retinotectal projection.
300 $a 75 p.
500 $a Adviser: Herwig Baier.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7089.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2008.
520 $a The retinotectal projection has long served as an experimentally accessible model for the study of topographic map formation and function. Retinal ganglion cells (RGCs) project to their midbrain target, the optic tectum, such that neighbor relationships are preserved between pre- and postsynaptic cells.
520 $a Organization of the map relies on first establishing positional information in the retina and tectum. Differentiating cells in the developing eye must be coded with positional information, giving them a molecular identity along the dorsal-ventral (DV), and anterior posterior (AP) axis. The DV relies on a cascade of secreted signalling factors which establish domains of expression for dorsal-specific and ventral-specific transcription factors. Through a behavioral forward genetic screen, we have identified a mutant, s327 , with an aberrant retinotectal projection. The unusual projection arises as a result of defective retinal patterning, specifically lacking expression of the dorsal marker tbx5. Cloning of the disrupted gene in s327 mutants has identified radar as a necessary and sufficient component for dorsal retinal specification.
520 $a Along the anterior-posterior axis, this process relies on repellant interactions between ephrin-A ligands and EphA receptors. Chemorepellant interactions alone, however, cannot explain the observed map. It has therefore been suggested that competitive interactions between RGCs cause posterior projection of RGC axons, and are necessary for correct topographic map development. Using larval zebrafish and a novel experimental paradigm, I have tested the role of proposed axon-axon competition during retinotectal projection, and found that RGC-RGC interactions do not play a significant role in determining distal target location in the retina, but do affect axon arbor morphology by restricting arbor branch number and location.
590 $a School code: 0034.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Physiology. $3 1017816
690 $a 0317
690 $a 0369
690 $a 0719
710 2 $a University of California, San Francisco. $b Biochemistry and Molecular Biology. $3 1263088
773 0 $t Dissertation Abstracts International $g 68-11B.
790 $a 0034
790 1 0 $a Baier, Herwig, $e advisor
790 1 0 $a Davis, Graeme W. $e committee member
790 1 0 $a Rubenstein, John L. $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3289323