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The Drosophila SF-1-like nuclear hor...

Allen, Anna Krueger.

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The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function./
Author:	Allen, Anna Krueger.
Description:	163 p.
Notes:	Adviser: Allan C. Spradling.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3288422
ISBN:	9780549311577

The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function.
Allen, Anna Krueger.

The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function. - 163 p.

Adviser: Allan C. Spradling.

Thesis (Ph.D.)--The Johns Hopkins University, 2008.

The nuclear hormone receptor Steroidogenic Factor -1 (SF-1) establishes and maintains circulating male or female steroid hormone production in vertebrates by regulating cytochrome P450 gene transcription in steroidogenic tissues. We find that the SF-1-like Drosophila nuclear hormone receptor HR39 also plays a role in sexual development. In Hr39 mutant females the sperm-storing spermathecae and its secretory products, as well as the parovaria, are absent or defective, causing female sterility. Spermathecae appear to function as secretory organs, and express genes that likely contribute to sperm maturation as well as storage. Hr39 mutation alters cytochrome P450 gene expression and causes the male-specific courtship gene takeout to be induced in the female reproductive tract. Our results suggest that spermathecae perform functions analogous to the mammalian epididymis, and that steroid signaling pathways act more similarly in controlling mammalian and invertebrate reproduction than previously believed.

ISBN: 9780549311577Subjects--Topical Terms:

1017730
Biology, Genetics.

The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function.
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020 $a 9780549311577
035 $a (UMI)AAI3288422
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040 $a UMI $c UMI
100 1 $a Allen, Anna Krueger. $3 1263081
245 1 4 $a The Drosophila SF-1-like nuclear hormone receptor Hr39 is essential for female reproductive tract development and function.
300 $a 163 p.
500 $a Adviser: Allan C. Spradling.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7087.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2008.
520 $a The nuclear hormone receptor Steroidogenic Factor -1 (SF-1) establishes and maintains circulating male or female steroid hormone production in vertebrates by regulating cytochrome P450 gene transcription in steroidogenic tissues. We find that the SF-1-like Drosophila nuclear hormone receptor HR39 also plays a role in sexual development. In Hr39 mutant females the sperm-storing spermathecae and its secretory products, as well as the parovaria, are absent or defective, causing female sterility. Spermathecae appear to function as secretory organs, and express genes that likely contribute to sperm maturation as well as storage. Hr39 mutation alters cytochrome P450 gene expression and causes the male-specific courtship gene takeout to be induced in the female reproductive tract. Our results suggest that spermathecae perform functions analogous to the mammalian epididymis, and that steroid signaling pathways act more similarly in controlling mammalian and invertebrate reproduction than previously believed.
590 $a School code: 0098.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
710 2 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 68-11B.
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790 1 0 $a Spradling, Allan C., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3288422