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Opioid receptors in aging and oxidat...

Raut, Atul M.

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Opioid receptors in aging and oxidative stress.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Opioid receptors in aging and oxidative stress./
Author:	Raut, Atul M.
Description:	181 p.
Notes:	Adviser: James W. Simpkins.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3286584
ISBN:	9780549289180

Opioid receptors in aging and oxidative stress.
Raut, Atul M.

Opioid receptors in aging and oxidative stress. - 181 p.

Adviser: James W. Simpkins.

Thesis (Ph.D.)--University of North Texas Health Science Center at Fort Worth, 2007.

The results from the in vivo and in vitro projects demonstrate the involvement of aging and oxidative stress in modulation of pain sensitivity, opioid-induced anti nociception and opioid receptor function and expression.

ISBN: 9780549289180Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Opioid receptors in aging and oxidative stress.
LDR:02867nam 2200313 a 45 001 938958
005 20110512
008 110512s2007 eng d
020 $a 9780549289180
035 $a (UMI)AAI3286584
035 $a AAI3286584
040 $a UMI $c UMI
100 1 $a Raut, Atul M. $3 1262933
245 1 0 $a Opioid receptors in aging and oxidative stress.
300 $a 181 p.
500 $a Adviser: James W. Simpkins.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6609.
502 $a Thesis (Ph.D.)--University of North Texas Health Science Center at Fort Worth, 2007.
520 $a The results from the in vivo and in vitro projects demonstrate the involvement of aging and oxidative stress in modulation of pain sensitivity, opioid-induced anti nociception and opioid receptor function and expression.
520 $a Oxidative stress has been implicated in aging and neurodegenerative disorders. Pain sensitivity and responses to opioids change with aging. The effect of aging and oxidative stress on opioid receptor system is not yet well understood. To study the effects of aging on pain sensitivity and opioid-induced antinociception, and to determine the possible association of oxidative stress with these pain parameters, in vivo studies were conducted. To further elucidate the effects of oxidative stress on opioid receptor proteins and their function, in vitro studies were carried out.
520 $a The effects of aging on pain sensitivity and opioid-induced antinociception were studied in male Fischer 344 rats. Oxidative stress markers in cerebral cortex, hippocampus, striatum and midbrain of these rats were estimated. It was concluded that sensitivity to nociceptive stimulus increases and responses to opioids decrease with aging and age-related oxidative damage is negatively correlated with opioid-induced antinociception.
520 $a To characterize the effects of oxidative stress on function of opioid receptors, changes in intracellular cyclic adenosine monophosphate (cAMP) were measured in human SK-N-SH neuronal cells under oxidative stress conditions. It was found that oxidative stress decreased the function of mu opioid receptor (MOR) but not that of delta or kappa opioid receptors (DOR and KOR respectively). Antioxidant intervention preserved the function of MOR.
520 $a Western immunoassays revealed that MOR but not DOR and KOR proteins were decreased under oxidative stress conditions. Thus, these findings show a selective impairment of the MOR function and reduction in MOR protein under conditions of oxidative stress.
590 $a School code: 1250.
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
710 2 0 $a University of North Texas Health Science Center at Fort Worth. $3 1021741
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 1250
790 1 0 $a Simpkins, James W., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3286584