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Mechanisms of motor learning mediate...

Willuhn, Ingo.

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Mechanisms of motor learning mediated by the striatum: Effects of cocaine.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mechanisms of motor learning mediated by the striatum: Effects of cocaine./
Author:	Willuhn, Ingo.
Description:	227 p.
Notes:	Adviser: Heinz Steiner.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3283812
ISBN:	9780549271413

Mechanisms of motor learning mediated by the striatum: Effects of cocaine.
Willuhn, Ingo.

Mechanisms of motor learning mediated by the striatum: Effects of cocaine. - 227 p.

Adviser: Heinz Steiner.

Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2007.

Psychostimulants induce various molecular changes in cortico-basal ganglia-cortical circuits. Such changes are thought to affect signaling cascades that mediate learning and thus produce aberrant learning implicated in addiction. Psychostimulant-induced changes in gene regulation are most pronounced in the sensorimotor striatum, a region involved in procedural motor learning. Gene expression in corticostriatal circuits is regulated by D1 dopamine receptors. I hypothesize that cocaine alters procedural motor learning and associated molecular processes in sensorimotor corticostriatal circuits via a D1 receptor-dependent mechanism.

ISBN: 9780549271413Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Mechanisms of motor learning mediated by the striatum: Effects of cocaine.
LDR:03735nam 2200385 a 45 001 938955
005 20110512
008 110512s2007 eng d
020 $a 9780549271413
035 $a (UMI)AAI3283812
035 $a AAI3283812
040 $a UMI $c UMI
100 1 $a Willuhn, Ingo. $3 1262929
245 1 0 $a Mechanisms of motor learning mediated by the striatum: Effects of cocaine.
300 $a 227 p.
500 $a Adviser: Heinz Steiner.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6520.
502 $a Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2007.
520 $a Psychostimulants induce various molecular changes in cortico-basal ganglia-cortical circuits. Such changes are thought to affect signaling cascades that mediate learning and thus produce aberrant learning implicated in addiction. Psychostimulant-induced changes in gene regulation are most pronounced in the sensorimotor striatum, a region involved in procedural motor learning. Gene expression in corticostriatal circuits is regulated by D1 dopamine receptors. I hypothesize that cocaine alters procedural motor learning and associated molecular processes in sensorimotor corticostriatal circuits via a D1 receptor-dependent mechanism.
520 $a In order to study the effects of cocaine on procedural motor learning and associated gene regulation, we developed a novel running-wheel paradigm. In this task, rats were trained on a running wheel (1-8 days) to learn a new motor skill. The animal's ability to control/balance the moving wheel (wheel skill) was assessed during training (intermediate memory) and up to 4 weeks after training (long-term memory). During training, rats received cocaine (pre-trial), a D1 receptor antagonist (pre-trial), and/or intrastriatal infusions of lidocaine (post-trial). Effects of running-wheel training on gene inducibility were assessed by a challenge injection of cocaine or vehicle one day after the last training session.
520 $a The animals learned the wheel skill within the first 2 days of training. Cocaine facilitated intermediate wheel-skill memory, stabilized skill-memory consolidation, but attenuated long-term skill-memory. Cocaine enhanced gene inducibility in both the striatum and the cortex in the wheel-skill learning phase (1 and 2 days) but not after extended training (8 days), preferentially in sensorimotor domains on the middle and caudal levels. These learning-associated changes were correlated between striatal sectors and their cortical input areas. Both behavioral and molecular effects of cocaine were dependent on stimulation of striatal D1 receptors.
520 $a Our combined behavioral and molecular findings indicate that cocaine alters wheel-skill learning and associated changes in gene regulation of sensorimotor corticostriatal circuits via D1 receptors in the striatum. Thus, cocaine may cause aberrant skill learning by abnormally enhancing and synchronizing molecular changes in cortical and striatal nodes of sensorimotor corticostriatal circuits. Such effects of cocaine may contribute to habitual drug intake in psychostimulant addiction.
590 $a School code: 1489.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0317
690 $a 0419
710 2 0 $a Rosalind Franklin University of Medicine and Science. $b Cellular & Molecular Pharmacology. $3 1262930
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 1489
790 1 0 $a Meredith, Gloria $e committee member
790 1 0 $a Oltmans, Gary $e committee member
790 1 0 $a Roberts, Barry $e committee member
790 1 0 $a Steiner, Heinz, $e advisor
790 1 0 $a West, Anthony $e committee member
790 1 0 $a Wolf, Marina $e committee member
790 1 0 $a Zhuang, Xiaoxi $e committee member
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3283812