東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Food ingredient design strategies fo...

Kwon, Young-In.

Linked to FindBook

Google Book

Amazon

博客來

Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals./
Author:	Kwon, Young-In.
Description:	430 p.
Notes:	Adviser: Kalidas Shetty.
Contained By:	Dissertation Abstracts International68-09B.
Subject:	Agriculture, Food Science and Technology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282735
ISBN:	9780549250333

Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals.
Kwon, Young-In.

Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals. - 430 p.

Adviser: Kalidas Shetty.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2007.

The chronic diseases such as diabetes mellitus and cardiovascular disease are among the leading causes of death globally. These are strongly associated with obesity as a result of change in dietary pattern towards high calories and reduced physical activity, which now affects both developing and developed countries. Excessive cellular energy from high calorie foods results in incomplete reduction of oxygen resulting in oxidative stress leading to reactive oxygen species (ROS). The harmful effects of ROS can be balanced by the combination of non-enzymatic antioxidants and antioxidant enzymes. Hence, the maintenance of balance between oxidants and antioxidants through well-designed diet that can modulate cellular protection through critical energy and reductant pathways coupled to antioxidant enzymes is essential.

ISBN: 9780549250333Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals.
LDR:03607nam 2200289 a 45 001 938951
005 20110512
008 110512s2007 eng d
020 $a 9780549250333
035 $a (UMI)AAI3282735
035 $a AAI3282735
040 $a UMI $c UMI
100 1 $a Kwon, Young-In. $3 1262925
245 1 0 $a Food ingredient design strategies for chemoprevention of disease using phenolic phytochemicals.
300 $a 430 p.
500 $a Adviser: Kalidas Shetty.
500 $a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5647.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2007.
520 $a The chronic diseases such as diabetes mellitus and cardiovascular disease are among the leading causes of death globally. These are strongly associated with obesity as a result of change in dietary pattern towards high calories and reduced physical activity, which now affects both developing and developed countries. Excessive cellular energy from high calorie foods results in incomplete reduction of oxygen resulting in oxidative stress leading to reactive oxygen species (ROS). The harmful effects of ROS can be balanced by the combination of non-enzymatic antioxidants and antioxidant enzymes. Hence, the maintenance of balance between oxidants and antioxidants through well-designed diet that can modulate cellular protection through critical energy and reductant pathways coupled to antioxidant enzymes is essential.
520 $a Therefore, the aim of this dissertation was to develop strategies for designing diets enriched in phenolic phytochemicals for chemoprevention of diseases. This was achieved through understanding the critical metabolic pathways contributing to cellular protection against oxidation dysfunction-linked chronic diseases.
520 $a Based on structure-function rationale, the potential antioxidant, anti-hyperglycemia and anti-hypertension functionality of plant foods such as clonal lines of Lamiaceae family, Rhodiola, wine, tea, vegetables (peppers, eggplant and pumpkin) and grains (corn and legume) were investigated. Results indicated that specific phenolic profiles had high anti-hyperglycemia and anti-hypertension potential which generally corresponded to total phenolic content and free radical scavenging-linked antioxidant activity. Dietary chemoprevention of bacterial pathogens such as Helicobacter pylori and Staphylococcus aureus was investigated through inhibition of critical control points that breakdown cellular energy and antioxidant pathways. Results indicated that lemon balm with the highest gallic acid and caffeic acid contents had potent anti-S. aureus activity. L-Lactic acid, a major food ingredient, had high anti-H. pylori activity through inhibition of proline dehydrogenase and catalase. Overall cellular protection through modulation of energy and reductant stimulating metabolic pathways was investigated in model eukaryotes. Rhodiola crenulata with high anti-hyperglycermia activity, induced apoptosis in V14a breast cancer cell line. Further, phenolic phytochemicals from R. crenulata protected Saccharomyces cerevisiae from UV-induced oxidative stress and delayed death. The cellular protection with phenolic phytochemicals was linked to modulation of proline-linked oxidative phosphorylation coupled to pentose phosphate pathway (PPP).
590 $a School code: 0118.
650 4 $a Agriculture, Food Science and Technology. $3 1017813
690 $a 0359
710 2 0 $a University of Massachusetts Amherst. $3 1019433
773 0 $t Dissertation Abstracts International $g 68-09B.
790 $a 0118
790 1 0 $a Shetty, Kalidas, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3282735