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Pharmacodynamics of IV citalopram us...

Bigos, Kristin L.

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Pharmacodynamics of IV citalopram using functional MRI.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Pharmacodynamics of IV citalopram using functional MRI./
Author:	Bigos, Kristin L.
Description:	200 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3710.
Contained By:	Dissertation Abstracts International68-06B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3270105
ISBN:	9780549092223

Pharmacodynamics of IV citalopram using functional MRI.
Bigos, Kristin L.

Pharmacodynamics of IV citalopram using functional MRI. - 200 p.

Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3710.

Thesis (Ph.D.)--University of Pittsburgh, 2007.

Although much is known about the role of serotonin (5-HT) in the pathophysiology of depression, little is known about the temporal and regional brain alterations in 5-HT as they relate to the treatment of depression and anxiety. This study aimed to evaluate the acute effects of the selective serotonin reuptake inhibitor (SSRI), citalopram, on neuronal activation elicited during an emotional task using functional MRI (fMRI) in healthy subjects. Eight healthy men completed the double-blind placebo-controlled crossover study of citalopram (20 mg infused over 30 min) and normal saline. Subjects performed the emotional task once before drug/placebo infusion (Faces 1) and twice during drug/placebo infusion, once early in the infusion (Faces 2) and once at the end of infusion (Faces 3).

ISBN: 9780549092223Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Pharmacodynamics of IV citalopram using functional MRI.
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035 $a (UMI)AAI3270105
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100 1 $a Bigos, Kristin L. $3 1262902
245 1 0 $a Pharmacodynamics of IV citalopram using functional MRI.
300 $a 200 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3710.
502 $a Thesis (Ph.D.)--University of Pittsburgh, 2007.
520 $a Although much is known about the role of serotonin (5-HT) in the pathophysiology of depression, little is known about the temporal and regional brain alterations in 5-HT as they relate to the treatment of depression and anxiety. This study aimed to evaluate the acute effects of the selective serotonin reuptake inhibitor (SSRI), citalopram, on neuronal activation elicited during an emotional task using functional MRI (fMRI) in healthy subjects. Eight healthy men completed the double-blind placebo-controlled crossover study of citalopram (20 mg infused over 30 min) and normal saline. Subjects performed the emotional task once before drug/placebo infusion (Faces 1) and twice during drug/placebo infusion, once early in the infusion (Faces 2) and once at the end of infusion (Faces 3).
520 $a A main effect of task was found in the L and R amygdala. A cluster in the right amygdala had increased activation for the Faces 2 task during the citalopram infusion, compared to the baseline Faces 1 task. An even greater bilateral amygdala response to citalopram was found at the end of infusion (Faces 3), when the citalopram concentrations approach their maxima, compared to the baseline Faces 1 task. This suggests that acute citalopram administration potentiates the amygdala response to emotional stimuli. An exploratory analysis was done using serotonin transporter genotype as a covariate. S allele carriers (2 s/s and 3 s/l) had a greater baseline amygdala response than l/l (n=3) homozygotes. However l/l homozygotes had a greater response to citalopram, comparing the Faces 3 to the Faces 1 task.
520 $a This study generated the first in vivo human data regarding the regional effects of acute intravenous SSRI administration on affective task-related neuronal activation. An understanding of the regional effects of SSRIs may aid in understanding the mechanism by which these agents produce their therapeutic effects. By including 5-HTTLPR genotype in the analyses, we may account for some of the variability in response to citalopram and other SSRIs. These efforts contribute to the identification of biological mechanisms and pathways that mediate response to SSRIs, and contribute to our understanding of individual differences in complex behaviors and vulnerability to psychiatric illnesses.
590 $a School code: 0178.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pharmacology. $3 1017717
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710 2 0 $a University of Pittsburgh. $3 958527
773 0 $t Dissertation Abstracts International $g 68-06B.
790 $a 0178
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3270105