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The role of poly (ADP-ribose) polyme...

Grivas, Paul Christopher.

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The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity./
Author:	Grivas, Paul Christopher.
Description:	153 p.
Notes:	Adviser: Raymond D. Harbison.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Health Sciences, Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260061

The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity.
Grivas, Paul Christopher.

The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity. - 153 p.

Adviser: Raymond D. Harbison.

Thesis (Ph.D.)--University of South Florida, 2007.

Carbon tetrachloride (CCl4) is a hepatotoxicant known to elevate alanine aminotransferase (ALT) and other liver enzyme levels, and cause lipid peroxidation, as well as centrilobular necrosis. A number of poly ADP-ribose polymerase (PARP) inhibitors were administered via intraperitoneal (i.p.) injections to male ICR mice as co-treatments at various time intervals relative to the CCl4. Aminophylline, a water soluble complex consisting of two molecules of theophylline bridged by ethylene diamine, was administered one-half hour, one hour and two hours after CCl4. The levels of ALT in the serum, as well as malondialdehyde and its equivalent markers of oxidative damage in the liver, were significantly reduced by aminophylline, relative to those in mice receiving only CCl4. The hepatoprotective effects of aminophylline were confirmed via the examination of histopathologic samples from the livers of mice receiving aminophylline in conjunction with CCl4 as opposed to those administered CCl4 alone. The potential benefit to society as a result of this research is that aminophylline, which has already been approved by the Food and Drug Administration (FDA), could potentially be administered in the event of an overexposure to CCl 4 or similar halocarbons to minimize the free radical-mediated hepatotoxicity resulting from overexposure.Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity.
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100 1 $a Grivas, Paul Christopher. $3 1262890
245 1 4 $a The role of poly (ADP-ribose) polymerase-1 inhibitors: Prevention of non glutathione-dependent carbon tetrachloride-induced hepatotoxicity.
300 $a 153 p.
500 $a Adviser: Raymond D. Harbison.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2314.
502 $a Thesis (Ph.D.)--University of South Florida, 2007.
520 $a Carbon tetrachloride (CCl4) is a hepatotoxicant known to elevate alanine aminotransferase (ALT) and other liver enzyme levels, and cause lipid peroxidation, as well as centrilobular necrosis. A number of poly ADP-ribose polymerase (PARP) inhibitors were administered via intraperitoneal (i.p.) injections to male ICR mice as co-treatments at various time intervals relative to the CCl4. Aminophylline, a water soluble complex consisting of two molecules of theophylline bridged by ethylene diamine, was administered one-half hour, one hour and two hours after CCl4. The levels of ALT in the serum, as well as malondialdehyde and its equivalent markers of oxidative damage in the liver, were significantly reduced by aminophylline, relative to those in mice receiving only CCl4. The hepatoprotective effects of aminophylline were confirmed via the examination of histopathologic samples from the livers of mice receiving aminophylline in conjunction with CCl4 as opposed to those administered CCl4 alone. The potential benefit to society as a result of this research is that aminophylline, which has already been approved by the Food and Drug Administration (FDA), could potentially be administered in the event of an overexposure to CCl 4 or similar halocarbons to minimize the free radical-mediated hepatotoxicity resulting from overexposure.
590 $a School code: 0206.
650 4 $a Health Sciences, Pathology. $3 1017854
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Toxicology. $3 1017752
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690 $a 0419
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710 2 0 $a University of South Florida. $3 1020446
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0206
790 1 0 $a Harbison, Raymond D., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260061