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The development of 2,3,7,8-tetrachlo...

Fried, Kristian Wolfgang.

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The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead./
Author:	Fried, Kristian Wolfgang.
Description:	182 p.
Notes:	Adviser: Karl K. Rozman.
Contained By:	Dissertation Abstracts International68-03B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3258378

The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead.
Fried, Kristian Wolfgang.

The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead. - 182 p.

Adviser: Karl K. Rozman.

Thesis (Ph.D.)--University of Kansas, 2007.

Dose-response relationships were developed for TCPT and TCDD regarding the reduction of serum IGF-1 levels in the rat. TCPT displayed in this regard also high efficacy, but very low potency compared to TCDD.Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead.
LDR:02027nam 2200301 a 45 001 938914
005 20110512
008 110512s2007 eng d
035 $a (UMI)AAI3258378
035 $a AAI3258378
040 $a UMI $c UMI
100 1 $a Fried, Kristian Wolfgang. $3 1262884
245 1 4 $a The development of 2,3,7,8-tetrachlorophenothiazine as a drug lead.
300 $a 182 p.
500 $a Adviser: Karl K. Rozman.
500 $a Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1602.
502 $a Thesis (Ph.D.)--University of Kansas, 2007.
520 $a Dose-response relationships were developed for TCPT and TCDD regarding the reduction of serum IGF-1 levels in the rat. TCPT displayed in this regard also high efficacy, but very low potency compared to TCDD.
520 $a Unlike TCDD, TCPT did not affect thyroid homeostasis at doses that lowered IGF-1 signaling. These findings suggest that TCPT could become a suitable drug lead.
520 $a The dioxin analogue 2,3,7,8-tetrachlorophenothiazine (TCPT) was synthesized and developed as a drug lead with potential applications in chemoprevention, body weight control, type II diabetes, contraception, and longevity. These well-documented effects of dioxins are believed to be mediated through two key mechanisms of action: AhR binding with downsteam induction of enzyme activity, and reduced IGF-1 signaling. The effects of TCPT on these pathways were investigated quantitatively.
520 $a TCPT showed an affinity to AhR similar to that of TCDD, and it induced EROD activity with high efficacy in vitro. Its potency regarding enzyme induction, however, was lower by two orders of magnitude compared to that of TCDD. Metabolism was demonstrated to yield low-potency derivatives.
590 $a School code: 0099.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0383
690 $a 0419
710 2 0 $a University of Kansas. $3 626626
773 0 $t Dissertation Abstracts International $g 68-03B.
790 $a 0099
790 1 0 $a Rozman, Karl K., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3258378