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Leukocytes from HIV-1 transgenic mic...

Koutrouby, Tara Beth.

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Leukocytes from HIV-1 transgenic mice adhere to extracellular matrix proteins.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Leukocytes from HIV-1 transgenic mice adhere to extracellular matrix proteins./
Author:	Koutrouby, Tara Beth.
Description:	47 p.
Notes:	Source: Masters Abstracts International, Volume: 40-06, page: 1495.
Contained By:	Masters Abstracts International40-06.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408905
ISBN:	0493625887

Leukocytes from HIV-1 transgenic mice adhere to extracellular matrix proteins.
Koutrouby, Tara Beth.

Leukocytes from HIV-1 transgenic mice adhere to extracellular matrix proteins. - 47 p.

Source: Masters Abstracts International, Volume: 40-06, page: 1495.

Thesis (M.S.)--Adelphi University, 2002.

Several studies have shown that HIV-1 infection increases leukocyte integrin expression and collagenase secretion. Based on these observations, it has been hypothesized that HIV-1 infected leukocytes localize in tissues and, subsequently cause tissue-specific pathogenesis. Peripheral blood lymphocytes from transgenic mice showed approximately a 3-fold increase in adhesion to fibronectin, laminin, and type IV collagen, while there was no significant difference in adhesion to type I collagen. Transgenic thymocytes also showed an approximate 3-fold adhesion increase to fibronectin and type IV collagen, and a 1.7 fold adhesion increase to laminin. Transgenic splenocytes showed approximately a 3-fold adhesion increase only to fibronectin. Further, other studies in our laboratory found that thymocytes and splenocytes from transgenic mice secreted an increased level of 92-kDa collagenase. An increase in the level of 92-kDa collagenase was also seen in the serum of transgenic mice. This study shows that, like HIV-1 infected cells, leukocytes from HIV-1 transgenic mice are also more adhesive to extracellular matrix proteins and secrete more extracellular matrix degrading enzymes. (Abstract shortened by UMI.)

ISBN: 0493625887Subjects--Topical Terms:

1017686
Biology, Cell.

Leukocytes from HIV-1 transgenic mice adhere to extracellular matrix proteins.
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520 $a Several studies have shown that HIV-1 infection increases leukocyte integrin expression and collagenase secretion. Based on these observations, it has been hypothesized that HIV-1 infected leukocytes localize in tissues and, subsequently cause tissue-specific pathogenesis. Peripheral blood lymphocytes from transgenic mice showed approximately a 3-fold increase in adhesion to fibronectin, laminin, and type IV collagen, while there was no significant difference in adhesion to type I collagen. Transgenic thymocytes also showed an approximate 3-fold adhesion increase to fibronectin and type IV collagen, and a 1.7 fold adhesion increase to laminin. Transgenic splenocytes showed approximately a 3-fold adhesion increase only to fibronectin. Further, other studies in our laboratory found that thymocytes and splenocytes from transgenic mice secreted an increased level of 92-kDa collagenase. An increase in the level of 92-kDa collagenase was also seen in the serum of transgenic mice. This study shows that, like HIV-1 infected cells, leukocytes from HIV-1 transgenic mice are also more adhesive to extracellular matrix proteins and secrete more extracellular matrix degrading enzymes. (Abstract shortened by UMI.)
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