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Induction of leukocyte apoptosis by ...

Uzarski, Rebecca Lynne.

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Induction of leukocyte apoptosis by trichothecene mycotoxins.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Induction of leukocyte apoptosis by trichothecene mycotoxins./
Author:	Uzarski, Rebecca Lynne.
Description:	130 p.
Notes:	Adviser: James J. Pestka.
Contained By:	Dissertation Abstracts International63-05B.
Subject:	Agriculture, Food Science and Technology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3053821
ISBN:	0493689192

Induction of leukocyte apoptosis by trichothecene mycotoxins.
Uzarski, Rebecca Lynne.

Induction of leukocyte apoptosis by trichothecene mycotoxins. - 130 p.

Adviser: James J. Pestka.

Thesis (Ph.D.)--Michigan State University, 2002.

Trichothecenes are secondary fungal metabolites produced by food-borne and environmental molds including <italic>Fusarium, Stachybotrys</italic>, and <italic>Myrothecium</italic>. Human and animal exposure may occur via consumption of mold-contaminated grains, inhalation of fungal spores present on water-damaged building materials, or airborne exposure during suspected chemical warfare. Trichothecenes are potent translational inhibitors which bind to the ribosomes of actively dividing leukocytes of the immune system. Exposure to trichothecenes results in decreased leukocyte numbers and impaired resistance to pathogens. The overall hypothesis of this dissertation is that trichothecene-induced immune suppression is mediated in part by the induction of leukocyte death by apoptosis. The specific objectives of these studies were to compare apoptosis induction by trichothecenes and other naturally occurring translational inhibitors, determine the physico-chemical components of the trichothecenes critical for the induction of apoptosis, investigate the augmentation of trichothecene-induced cell death by inflammatory agents, and determine the signal transduction mechanisms critical for trichothecene-induced apoptosis. Comparisons of translational inhibitors suggested that trichothecenes were among the most potent inducers of leukocyte apoptosis when compared to other natural toxins. Multiple physico-chemical factors critical to transport and ribosomal binding contribute to the apoptotic actions of the trichothecenes including electrostatic interactions, and molecular shape. Trichothecene-induced leukocyte apoptosis may be augmented by signal components of stress and inflammation such as TNF-α and Fas ligand. Activation of mitogen activated protein kinases (MAPKs) appears to be an early, critical step in the development of leukocyte apoptosis induced by trichothecenes or potentiated by inflammatory agents. Taken together, these studies contribute to our knowledge of the mechanism of leukocyte apoptosis by the trichothecene mycotoxins and may facilitate risk assessment studies for this group of natural toxins.

ISBN: 0493689192Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Induction of leukocyte apoptosis by trichothecene mycotoxins.
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020 $a 0493689192
035 $a (UnM)AAI3053821
035 $a AAI3053821
040 $a UnM $c UnM
100 1 $a Uzarski, Rebecca Lynne. $3 1261807
245 1 0 $a Induction of leukocyte apoptosis by trichothecene mycotoxins.
300 $a 130 p.
500 $a Adviser: James J. Pestka.
500 $a Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2126.
502 $a Thesis (Ph.D.)--Michigan State University, 2002.
520 $a Trichothecenes are secondary fungal metabolites produced by food-borne and environmental molds including <italic>Fusarium, Stachybotrys</italic>, and <italic>Myrothecium</italic>. Human and animal exposure may occur via consumption of mold-contaminated grains, inhalation of fungal spores present on water-damaged building materials, or airborne exposure during suspected chemical warfare. Trichothecenes are potent translational inhibitors which bind to the ribosomes of actively dividing leukocytes of the immune system. Exposure to trichothecenes results in decreased leukocyte numbers and impaired resistance to pathogens. The overall hypothesis of this dissertation is that trichothecene-induced immune suppression is mediated in part by the induction of leukocyte death by apoptosis. The specific objectives of these studies were to compare apoptosis induction by trichothecenes and other naturally occurring translational inhibitors, determine the physico-chemical components of the trichothecenes critical for the induction of apoptosis, investigate the augmentation of trichothecene-induced cell death by inflammatory agents, and determine the signal transduction mechanisms critical for trichothecene-induced apoptosis. Comparisons of translational inhibitors suggested that trichothecenes were among the most potent inducers of leukocyte apoptosis when compared to other natural toxins. Multiple physico-chemical factors critical to transport and ribosomal binding contribute to the apoptotic actions of the trichothecenes including electrostatic interactions, and molecular shape. Trichothecene-induced leukocyte apoptosis may be augmented by signal components of stress and inflammation such as TNF-α and Fas ligand. Activation of mitogen activated protein kinases (MAPKs) appears to be an early, critical step in the development of leukocyte apoptosis induced by trichothecenes or potentiated by inflammatory agents. Taken together, these studies contribute to our knowledge of the mechanism of leukocyte apoptosis by the trichothecene mycotoxins and may facilitate risk assessment studies for this group of natural toxins.
590 $a School code: 0128.
650 4 $a Agriculture, Food Science and Technology. $3 1017813
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0359
690 $a 0383
710 2 0 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 63-05B.
790 $a 0128
790 1 0 $a Pestka, James J., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3053821