東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Central and peripheral analgesic pro...

Schwarz, Stephan Karl Walter.

Linked to FindBook

Google Book

Amazon

博客來

Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade./
Author:	Schwarz, Stephan Karl Walter.
Description:	171 p.
Notes:	Advisers: Ernie Puil; Bernard A. MacLeod.
Contained By:	Dissertation Abstracts International63-10B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ73244
ISBN:	0612732444

Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade.
Schwarz, Stephan Karl Walter.

Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade. - 171 p.

Advisers: Ernie Puil; Bernard A. MacLeod.

Thesis (Ph.D.)--The University of British Columbia (Canada), 2002.

This thesis is dedicated to the pharmacology & therapeutics of local anesthetics, with a specific focus on their analgesic properties.

ISBN: 0612732444Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade.
LDR:03943nam 2200313 a 45 001 937883
005 20110511
008 110511s2002 eng d
020 $a 0612732444
035 $a (UnM)AAINQ73244
035 $a AAINQ73244
040 $a UnM $c UnM
100 1 $a Schwarz, Stephan Karl Walter. $3 1261739
245 1 0 $a Central and peripheral analgesic properties of local anesthetics: Effects of lidocaine on thalamic neurons and efficacy of ropivacaine in femoral 3-in-1 nerve blockade.
300 $a 171 p.
500 $a Advisers: Ernie Puil; Bernard A. MacLeod.
500 $a Source: Dissertation Abstracts International, Volume: 63-10, Section: B, page: 4616.
502 $a Thesis (Ph.D.)--The University of British Columbia (Canada), 2002.
520 $a This thesis is dedicated to the pharmacology & therapeutics of local anesthetics, with a specific focus on their analgesic properties.
520 $a The specific objective of the laboratory studies was to define the concentration-dependent effects of lidocaine on the membrane properties and excitability of neurons in the ventral posterior lateral thalamic nucleus (VPL), a major somatosensory and nociceptive relay station that plays a central role in pain states. Lidocaine produces central analgesia and sedation when present in the systemic circulation at low concentrations, and evidence implicates VPL neurons in these actions. Differential interference contrast infrared (DIC-IR) videomicroscopy-guided whole-cell patch clamp techniques were used to record from VPL neurons in rat brain slice preparations. Low, analgesic lidocaine concentrations (10 μM) significantly decreased neuronal input resistance (<italic>R</italic> i), which shunted action potentials, increased current thresholds, and reduced tonic firing. The effects were not associated with the classic signs of Na<super>+</super> conductance blockade. The GABAA receptor antagonist, bicuculline, had no effect on the lidocaine-induced shunt. Higher lidocaine concentrations (≥300 μM; clinically CNS-toxic) did not decrease <italic> R</italic>i but reversibly unmasked high threshold Ca<super>2+ </super> spikes (HTSs), susceptible to blockade by Cd<super>2+</super>. Extracellular QX-314, a quaternary lidocaine analogue, increased rather than decreased <italic> R</italic>i. Similarly, neither procainamide nor bupivacaine reduced <italic> R</italic>i. In summary, these studies identified novel actions of lidocaine in the thalamus, distinct from the classic effects on Na<super> +</super> conductance. The observation of an unmasking of high threshold Ca<super> 2+</super> spikes is in contrast to previous studies in other tissues showing that lidocaine blocks Ca<super>2+</super> conductances, and is of potential significance for the mechanisms of local anesthetic CNS toxicity.
520 $a The purpose of the clinical studies was to test if postoperative pain control in patients undergoing arthroscopic anterior cruciate ligament reconstruction (ACLR) under general anesthesia is improved by addition of a preincisional femoral 3-in-1 block with ropivacaine 0.2% to standard intra-articular instillation at the end of surgery. In a prospective, randomized, controlled, double-blind trial (RCT), 44 patients scheduled for inpatient ACLR were studied. In conclusion, the clinical studies demonstrated no significant effect in an RCT of a femoral 3-in-1 block with ropivacaine 0.2% on postoperative analgesic consumption, compared to intra-articular instillation alone, in patients undergoing ACLR under general anesthesia. (Abstract shortened by UMI.)
590 $a School code: 2500.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0317
690 $a 0419
710 2 0 $a The University of British Columbia (Canada). $3 626643
773 0 $t Dissertation Abstracts International $g 63-10B.
790 $a 2500
790 1 0 $a MacLeod, Bernard A., $e advisor
790 1 0 $a Puil, Ernie, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ73244