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Understanding fluidic mechanics and ...

Qiu, Xiangming Charmaine.

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Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions./
作者:	Qiu, Xiangming Charmaine.
面頁冊數:	199 p.
附註:	Adviser: Jed Harrison.
Contained By:	Dissertation Abstracts International60-08B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ39584
ISBN:	0612395847

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
Qiu, Xiangming Charmaine.

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions. - 199 p.

Adviser: Jed Harrison.

Thesis (Ph.D.)--University of Alberta (Canada), 1999.

In the past few years much attention has been given to performing separations in microfabricated devices. Of all the reported μ-TAS chip devices, those based on electrically driven separations such as capillary electrophoresis have been the most successful. The power of these devices lies not only in the highly efficient, rapid separations, but also in the very precise, valveless fluid manipulation in the etched microchannel networks. While the demand for these devices continues to increase and the commercialization as analysis tool is underway, the challenges remaining are better understanding of the fluidic mechanism in the microfabricated channels and fully automation on-chip.

ISBN: 0612395847Subjects--Topical Terms:

586156
Chemistry, Analytical.

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
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245 1 0 $a Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
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500 $a Source: Dissertation Abstracts International, Volume: 60-08, Section: B, page: 3915.
502 $a Thesis (Ph.D.)--University of Alberta (Canada), 1999.
520 $a In the past few years much attention has been given to performing separations in microfabricated devices. Of all the reported μ-TAS chip devices, those based on electrically driven separations such as capillary electrophoresis have been the most successful. The power of these devices lies not only in the highly efficient, rapid separations, but also in the very precise, valveless fluid manipulation in the etched microchannel networks. While the demand for these devices continues to increase and the commercialization as analysis tool is underway, the challenges remaining are better understanding of the fluidic mechanism in the microfabricated channels and fully automation on-chip.
520 $a As applications for microfluidic systems become increasingly complex, design techniques based on the fluidic mechanism inside the microfabricated channel networks are essential to quality solvent delivery and mixing. We present here the experimental results from channels with a “T” intersection showing how the fluidic flow behavior would be affected by the side channel length and its location on the main channel. We also showed the deviation of the measured dye velocity from the simple electroosmotic prediction when the fluid had imbalanced <math> <f> <g>z</g></f> </math> potential inside the system. Our results are, comparable to the fluidic model prediction.
520 $a The chemical processing for complete on-chip immunoassays has been achieved. The integrated immunoreactor, which incorporates a method for performing on-chip calibration, on-chip mixing, reaction and separation of immunoreagents, samples and products are presented. This platform contains on-chip calibration standards for routing quantitation of samples and for internal calibration dilution. The success of this onboard calibration demonstrated the precise fluid control on the microfabricated channels, and promised the potential possibility of fully automation on chip.
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