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Understanding fluidic mechanics and ...

Qiu, Xiangming Charmaine.

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Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions./
Author:	Qiu, Xiangming Charmaine.
Description:	199 p.
Notes:	Adviser: Jed Harrison.
Contained By:	Dissertation Abstracts International60-08B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ39584
ISBN:	0612395847

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
Qiu, Xiangming Charmaine.

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions. - 199 p.

Adviser: Jed Harrison.

Thesis (Ph.D.)--University of Alberta (Canada), 1999.

In the past few years much attention has been given to performing separations in microfabricated devices. Of all the reported μ-TAS chip devices, those based on electrically driven separations such as capillary electrophoresis have been the most successful. The power of these devices lies not only in the highly efficient, rapid separations, but also in the very precise, valveless fluid manipulation in the etched microchannel networks. While the demand for these devices continues to increase and the commercialization as analysis tool is underway, the challenges remaining are better understanding of the fluidic mechanism in the microfabricated channels and fully automation on-chip.

ISBN: 0612395847Subjects--Topical Terms:

586156
Chemistry, Analytical.

Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
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020 $a 0612395847
035 $a (UnM)AAINQ39584
035 $a AAINQ39584
040 $a UnM $c UnM
100 1 $a Qiu, Xiangming Charmaine. $3 1261720
245 1 0 $a Understanding fluidic mechanics and its application to integrating calibration with on-chip immunological reactions.
300 $a 199 p.
500 $a Adviser: Jed Harrison.
500 $a Source: Dissertation Abstracts International, Volume: 60-08, Section: B, page: 3915.
502 $a Thesis (Ph.D.)--University of Alberta (Canada), 1999.
520 $a In the past few years much attention has been given to performing separations in microfabricated devices. Of all the reported μ-TAS chip devices, those based on electrically driven separations such as capillary electrophoresis have been the most successful. The power of these devices lies not only in the highly efficient, rapid separations, but also in the very precise, valveless fluid manipulation in the etched microchannel networks. While the demand for these devices continues to increase and the commercialization as analysis tool is underway, the challenges remaining are better understanding of the fluidic mechanism in the microfabricated channels and fully automation on-chip.
520 $a As applications for microfluidic systems become increasingly complex, design techniques based on the fluidic mechanism inside the microfabricated channel networks are essential to quality solvent delivery and mixing. We present here the experimental results from channels with a “T” intersection showing how the fluidic flow behavior would be affected by the side channel length and its location on the main channel. We also showed the deviation of the measured dye velocity from the simple electroosmotic prediction when the fluid had imbalanced <math> <f> <g>z</g></f> </math> potential inside the system. Our results are, comparable to the fluidic model prediction.
520 $a The chemical processing for complete on-chip immunoassays has been achieved. The integrated immunoreactor, which incorporates a method for performing on-chip calibration, on-chip mixing, reaction and separation of immunoreagents, samples and products are presented. This platform contains on-chip calibration standards for routing quantitation of samples and for internal calibration dilution. The success of this onboard calibration demonstrated the precise fluid control on the microfabricated channels, and promised the potential possibility of fully automation on chip.
590 $a School code: 0351.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
690 $a 0486
690 $a 0541
690 $a 0544
710 2 0 $a University of Alberta (Canada). $3 626651
773 0 $t Dissertation Abstracts International $g 60-08B.
790 $a 0351
790 1 0 $a Harrison, Jed, $e advisor
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ39584