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Self-assembly behavior of lipids at ...

Pautot, Sophie.

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Self-assembly behavior of lipids at an oil-water interface.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Self-assembly behavior of lipids at an oil-water interface./
Author:	Pautot, Sophie.
Description:	111 p.
Notes:	Adviser: David A. Weitz.
Contained By:	Dissertation Abstracts International63-04B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051255
ISBN:	0493658297

Self-assembly behavior of lipids at an oil-water interface.
Pautot, Sophie.

Self-assembly behavior of lipids at an oil-water interface. - 111 p.

Adviser: David A. Weitz.

Thesis (Ph.D.)--Harvard University, 2002.

The hydrophilic and hydrophobic properties of lipid molecules enable them to organize into large structures when dissolved in water or in oil. Under certain conditions and with the right they can organize into micellar or into lamellar phases under certain conditions and with the right system composition. The equilibrium phase of lipids have been well studied. In this work we observe the behavior of lipids at an oil-water interface, and we investigate the molecular assembly that can result in the presence of lipids at an oil-water interface.

ISBN: 0493658297Subjects--Topical Terms:

1019105
Biophysics, General.

Self-assembly behavior of lipids at an oil-water interface.
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100 1 $a Pautot, Sophie. $3 1260172
245 1 0 $a Self-assembly behavior of lipids at an oil-water interface.
300 $a 111 p.
500 $a Adviser: David A. Weitz.
500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1897.
502 $a Thesis (Ph.D.)--Harvard University, 2002.
520 $a The hydrophilic and hydrophobic properties of lipid molecules enable them to organize into large structures when dissolved in water or in oil. Under certain conditions and with the right they can organize into micellar or into lamellar phases under certain conditions and with the right system composition. The equilibrium phase of lipids have been well studied. In this work we observe the behavior of lipids at an oil-water interface, and we investigate the molecular assembly that can result in the presence of lipids at an oil-water interface.
520 $a We have established that lipids can be used as a surfactant to stabilize water droplets in oil, and we have developed a new method, a reverse emulsion technique, that allows us to use these emulsions to assemble unilamellar vesicles with a high encapsulation yield. The vesicle bilayer is formed from the assembly of two monolayers formed independently and we have proven that this technique offers the possibility to directly assemble asymmetric bilayer. Because the encapsulated phase remains contained at all time by a surfactant layer the reactivity of the molecules initially encapsulated can be preserved. We have demonstrated using fluorescence measurement that the vesicles formed can be used as micro-reactor where reactive molecules can be encapsulated and their activity remotely triggered. This technique is not limited to lipids and we have demonstrated that the process can also be applied to other amphiphilic molecules such as polymers or synthetic surfactants.
520 $a In addition, we have used dynamic light scattering to study the size of the inverted emulsion stabilized with lipids as a function of the shear applied to the suspension. We have established that a water drop injected in an alkane solution such as dodecane lead to the spontaneous formation of emulsion droplet. Moreover we have demonstrated that the spontaneous emulsification is due to the swelling of a lyotropic semi-crystalline phase which forms at the dodecane-water interface. We have observed by optical microscopy that large droplet composed of lipid and water grow at the interface and lead to the formation of onion like assembly in dodecane.
590 $a School code: 0084.
650 4 $a Biophysics, General. $3 1019105
650 4 $a Physics, Condensed Matter. $3 1018743
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710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 63-04B.
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791 $a Ph.D.
792 $a 2002
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