東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Effets antiarythmiques et proarythmi...

Derakhchan, Katayoun.

Linked to FindBook

Google Book

Amazon

博客來

Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text)./
Author:	Derakhchan, Katayoun.
Description:	258 p.
Notes:	Directeur: Rene Cardinal.
Contained By:	Dissertation Abstracts International63-10B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ73473
ISBN:	0612734730

Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text).
Derakhchan, Katayoun.

Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text). - 258 p.

Directeur: Rene Cardinal.

Thesis (Ph.D.)--Universite de Montreal (Canada), 2002.

In the first part, we investigated how the antiarrhythmic action of <italic> d</italic>-sotalol might be related to modifications of reentrant pathways. We found that <italic>d</italic>-sotalol did not prevent the induction of ventricular arrhythmias by programmed stimulation but it significantly prolonged the cycle length and reduced the duration of both the monomorphic tachycardias and the polymorphic ones.

ISBN: 0612734730Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text).
LDR:03887nam 2200325 a 45 001 935673
005 20110510
008 110510s2002 d
020 $a 0612734730
035 $a (UnM)AAINQ73473
035 $a AAINQ73473
040 $a UnM $c UnM
100 1 $a Derakhchan, Katayoun. $3 1259380
245 1 0 $a Effets antiarythmiques et proarythmiques du d-sotalol sur les arythmies cardiaques ventriculaires etudies chez le chien (French and English text).
300 $a 258 p.
500 $a Directeur: Rene Cardinal.
500 $a Source: Dissertation Abstracts International, Volume: 63-10, Section: B, page: 4612.
502 $a Thesis (Ph.D.)--Universite de Montreal (Canada), 2002.
520 $a In the first part, we investigated how the antiarrhythmic action of <italic> d</italic>-sotalol might be related to modifications of reentrant pathways. We found that <italic>d</italic>-sotalol did not prevent the induction of ventricular arrhythmias by programmed stimulation but it significantly prolonged the cycle length and reduced the duration of both the monomorphic tachycardias and the polymorphic ones.
520 $a The mapping data reported in this study show that during monomorphic ventricular tachycardias (<italic>1</italic>) drug-induced prolongation of the tachycardia cycle length occurred as a result of conversion of arcs of functional dissociation or pseudo-block into areas of inexcitability without any further reduction in the magnitude of the -dV/dt<sub>max</sub>, and (<italic> 2</italic>) drug-induced abbreviation of tachycardia duration resulted from an increased propensity for block along reentrant pathways. During polymorphic ventricular tachycardias (PVTs), these effects were associated with a reduction in the complexity of the activation patterns and, in particular, a reduction in the number of breakthrough areas, suggesting that <italic>d</italic>-sotalol may be effective against fast ventricular tachycardias in spite of the reverse use-dependence displayed by class III drugs.
520 $a In the second study, we tried to clarify the mechanism of torsades de pointes related to excessive prolongation of the action potential duration in the presence of <italic>d</italic>-sotalol. Epicardial mapping and unipolar electrogram recordings from selected endocardial and intramural sites were used to measure activation times as well as activation-recovery intervals (ARI).
520 $a In the third study, we investigated whether the changing patterns of <italic> d</italic>-sotalol-induced PVTs might be related to the shifting position of epicardial breakthroughs and arcs of functional dissociation of reentrant wave fronts in the vicinity of areas of marked dispersion in repolarization intervals.
520 $a In conclusion, the first study is consistent with an action of <italic> d</italic>-sotalol on reentrant pathways in ischemically-damaged myocardium and would predict a relatively greater efficacy against rapid polymorphic ventricular tachycardias and ventricular fibrillation than in completely suppressing sustained monomorphic ventricular tachycardias. The second and the third study suggest that PVTs occurring spontaneously under conditions of delayed repolarisation originate from shifting sites in the ventricular conduction system and that reentrant activity shifting between various regions of the ventricle may occur in later beats of the more sustained arrhythmias and the drift in the position of epicardial breakthroughs between various areas of marked ARI dispersion prolongs the life spans of PVTs. (Abstract shortened by UMI.)
590 $a School code: 0992.
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
710 2 0 $a Universite de Montreal (Canada). $3 1018132
773 0 $t Dissertation Abstracts International $g 63-10B.
790 $a 0992
790 1 0 $a Cardinal, Rene, $e advisor
791 $a Ph.D.
792 $a 2002
793 $a French and English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ73473