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Genetic dissection of zebrafish gast...

Marlow, Florence Louise.

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Genetic dissection of zebrafish gastrulation and tail morphogenesis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genetic dissection of zebrafish gastrulation and tail morphogenesis./
Author:	Marlow, Florence Louise.
Description:	198 p.
Notes:	Director: Lilianna Solnica-Krezel.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3085782

Genetic dissection of zebrafish gastrulation and tail morphogenesis.
Marlow, Florence Louise.

Genetic dissection of zebrafish gastrulation and tail morphogenesis. - 198 p.

Director: Lilianna Solnica-Krezel.

Thesis (Ph.D.)--Vanderbilt University, 2003.

During vertebrate gastrulation convergence and extension movements narrow the medio-lateral axis and contribute to lengthening of the anterior posterior axis to shape the head and anterior trunk. Recently much has been discovered about the molecules and cell behaviors mediating gastrulation movements in the zebrafish.Subjects--Topical Terms:

1017730
Biology, Genetics.

Genetic dissection of zebrafish gastrulation and tail morphogenesis.
LDR:02679nam 2200289 a 45 001 934741
005 20110509
008 110509s2003 eng d
035 $a (UnM)AAI3085782
035 $a AAI3085782
040 $a UnM $c UnM
100 1 $a Marlow, Florence Louise. $3 1258440
245 1 0 $a Genetic dissection of zebrafish gastrulation and tail morphogenesis.
300 $a 198 p.
500 $a Director: Lilianna Solnica-Krezel.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1097.
502 $a Thesis (Ph.D.)--Vanderbilt University, 2003.
520 $a During vertebrate gastrulation convergence and extension movements narrow the medio-lateral axis and contribute to lengthening of the anterior posterior axis to shape the head and anterior trunk. Recently much has been discovered about the molecules and cell behaviors mediating gastrulation movements in the zebrafish.
520 $a This work describes the cloning of zebrafish <italic>rho kinase 2</italic> and <italic>myosin regulatory light chain 2a</italic> and <italic>2b</italic>. The involvement of these genes in regulating cell motility in culture together with their expression in gastrula suggested that they might regulate gastrulation movements. Functional analysis shows that reduction of Rok2 function, or expression of a constitutively active Mlc2a disrupts gastrulation. We correlate impaired dorsal movement with disruption of polarized morphology in cells expressing dominant negative Rok2. Cell transplantation reveals that both cell intrinsic properties and intercellular interactions mediate acquisition of polarized cell morphology. Molecular epistasis analysis, and the ability of Wnt5 and Wnt11 to modulate Rok2 intracellular distribution identify Rok2 as a target of a non-canonical Wnt pathway regulating polarized cell behaviors that underlie convergence and extension.
520 $a As gastrulation ends, ventral and dorsal blastoderm cells meet and close over the yolk, forming the tailbud. Despite detailed analysis of cell movements within the tailbud, the genes required for tailbud morphogenesis are not known. Our genetic studies identify synergistic regulation of these cell movements by genes that regulate C&E in gastrula, <italic>pipetail/wnt5, knypek, </italic> and <italic>no tail</italic>. Therefore, tailbud formation involves a continuation of gastrulation mechanisms.
590 $a School code: 0242.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
710 2 0 $a Vanderbilt University. $3 1017501
773 0 $t Dissertation Abstracts International $g 64-03B.
790 $a 0242
790 1 0 $a Solnica-Krezel, Lilianna, $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3085782