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Controlled drug release from compres...

Aksornkoae, Napasinee.

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Controlled drug release from compressed matrices prepared with carrageenans.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Controlled drug release from compressed matrices prepared with carrageenans./
Author:	Aksornkoae, Napasinee.
Description:	236 p.
Notes:	Adviser: Atul J. Shukla.
Contained By:	Dissertation Abstracts International63-09B.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3063782
ISBN:	0493824421

Controlled drug release from compressed matrices prepared with carrageenans.
Aksornkoae, Napasinee.

Controlled drug release from compressed matrices prepared with carrageenans. - 236 p.

Adviser: Atul J. Shukla.

Thesis (Ph.D.)--The University of Tennessee Center for the Health Sciences, 2002.

The objective of this study was to evaluate the feasibility of using carrageenans to control the release of highly water-soluble drug as well as to elucidate the mechanism of drug release from tablets containing carrageenans. In addition, the effect of formulation variables including type (iota, lambda and kappa) and concentration (30, 40, and 50% w/w) of carrageenans and types of excipients (spray-dried lactose, microcrystalline cellulose and dicalcium phosphate dihydrate) and the effect of dissolution factors including type and pH and ionic strength of dissolution media on drug release were also evaluated.

ISBN: 0493824421Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Controlled drug release from compressed matrices prepared with carrageenans.
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020 $a 0493824421
035 $a (UnM)AAI3063782
035 $a AAI3063782
040 $a UnM $c UnM
100 1 $a Aksornkoae, Napasinee. $3 1256741
245 1 0 $a Controlled drug release from compressed matrices prepared with carrageenans.
300 $a 236 p.
500 $a Adviser: Atul J. Shukla.
500 $a Source: Dissertation Abstracts International, Volume: 63-09, Section: B, page: 4132.
502 $a Thesis (Ph.D.)--The University of Tennessee Center for the Health Sciences, 2002.
520 $a The objective of this study was to evaluate the feasibility of using carrageenans to control the release of highly water-soluble drug as well as to elucidate the mechanism of drug release from tablets containing carrageenans. In addition, the effect of formulation variables including type (iota, lambda and kappa) and concentration (30, 40, and 50% w/w) of carrageenans and types of excipients (spray-dried lactose, microcrystalline cellulose and dicalcium phosphate dihydrate) and the effect of dissolution factors including type and pH and ionic strength of dissolution media on drug release were also evaluated.
520 $a Granules were prepared from the blend of propranolol hydrochloride, carrageenans, polyethylene glycol (PEG) 8000 and filler using hot-melt granulation technique. The resulting granules were compressed on a rotary tablet press. <italic> In vitro</italic> drug release from tablets was tested in simulated gastric fluid (pH-1.2), simulated intestinal fluid (pH-7.2) and deionized water (pH-5.6) using USP apparatus I (basket method). In addition, the change in tablet volume and tablet weight at different time intervals was also recorded. The interaction between model drug and carrageenans was also evaluated using centrifugation method.
520 $a The overall drug release mechanism was found to be dependent on type and concentration of carrageenans. Tablets containing kappa carrageenan did not sustain the drug release due to tablet disintegration. However, controlled drug release was obtained from tablets containing iota and lambda carrageenans. High concentration of iota carrageenan must be used to achieve controlled drug release. Drug release from tablet containing iota carrageenan was controlled by a combination of diffusion and swelling/relaxation. For lambda carrageenans, regardless of molecular weight, the drug release was changed from diffusion to relaxation with increasing the concentration. The change in filler type significantly affected the rate of drug release. In addition, type, pH and ionic strength of the dissolution media also played an important role on the drug release as well as the swelling and erosion of carrageenans. Tablets containing iota carrageenan swelled to a greater extent as compared to that of lambda carrageenan. Also, there is an ionic interaction of the basic drug and carrageenan resulting in retarding the drug release.
590 $a School code: 0783.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 0 $a The University of Tennessee Center for the Health Sciences. $3 1252844
773 0 $t Dissertation Abstracts International $g 63-09B.
790 $a 0783
790 1 0 $a Shukla, Atul J., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3063782