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Characterization of Sindbis virus- a...

Nargi, Jennifer Laura.

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Characterization of Sindbis virus- and antioxidant-induced cell death.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Characterization of Sindbis virus- and antioxidant-induced cell death./
Author:	Nargi, Jennifer Laura.
Description:	255 p.
Notes:	Adviser: Diane E. Griffin.
Contained By:	Dissertation Abstracts International62-02B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3006317
ISBN:	0493156321

Characterization of Sindbis virus- and antioxidant-induced cell death.
Nargi, Jennifer Laura.

Characterization of Sindbis virus- and antioxidant-induced cell death. - 255 p.

Adviser: Diane E. Griffin.

Thesis (Ph.D.)--The Johns Hopkins University, 2001.

Although development and homeostasis of multicellular organisms is critically dependent upon apoptotic cell death, regulation of the cell death process is not fully understood. These studies were designed to identify factors that contribute to Sindbis virus (SV) and antioxidant-induced cell death and to better understand the cell death process following SV infection. The first set of experiments shows that glutamate excitotoxicity contributes to SV-induced death <italic>in vitro</italic> and <italic>in vivo</italic>, that SV-induced death can be either apoptotic or necrotic and that bystander cell death occurs in uninfected cells. The second set of experiments shows that poly (ADP-ribose) polymerase activation contributes to SV-induced apoptotic cell death and examines the role that cyclin-dependent kinase activation plays in cell death following SV infection. The last part of this study identifies cell cycle and cell death regulatory factors involved in antioxidant-induced growth arrest and cell death in colorectal carcinoma cells. These studies contribute to understanding the regulation of apoptotic cell death, a critical process which leads to disease if unregulated.

ISBN: 0493156321Subjects--Topical Terms:

1017734
Biology, Microbiology.

Characterization of Sindbis virus- and antioxidant-induced cell death.
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020 $a 0493156321
035 $a (UnM)AAI3006317
035 $a AAI3006317
040 $a UnM $c UnM
100 1 $a Nargi, Jennifer Laura. $3 1256300
245 1 0 $a Characterization of Sindbis virus- and antioxidant-induced cell death.
300 $a 255 p.
500 $a Adviser: Diane E. Griffin.
500 $a Source: Dissertation Abstracts International, Volume: 62-02, Section: B, page: 0676.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2001.
520 $a Although development and homeostasis of multicellular organisms is critically dependent upon apoptotic cell death, regulation of the cell death process is not fully understood. These studies were designed to identify factors that contribute to Sindbis virus (SV) and antioxidant-induced cell death and to better understand the cell death process following SV infection. The first set of experiments shows that glutamate excitotoxicity contributes to SV-induced death <italic>in vitro</italic> and <italic>in vivo</italic>, that SV-induced death can be either apoptotic or necrotic and that bystander cell death occurs in uninfected cells. The second set of experiments shows that poly (ADP-ribose) polymerase activation contributes to SV-induced apoptotic cell death and examines the role that cyclin-dependent kinase activation plays in cell death following SV infection. The last part of this study identifies cell cycle and cell death regulatory factors involved in antioxidant-induced growth arrest and cell death in colorectal carcinoma cells. These studies contribute to understanding the regulation of apoptotic cell death, a critical process which leads to disease if unregulated.
590 $a School code: 0098.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0317
690 $a 0410
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 62-02B.
790 $a 0098
790 1 0 $a Griffin, Diane E., $e advisor
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3006317