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Aerobic exercise training effects on...

Drouin, Jacqueline.

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Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer./
Author:	Drouin, Jacqueline.
Description:	142 p.
Notes:	Adviser: Donald Marcotte.
Contained By:	Dissertation Abstracts International63-03B.
Subject:	Health Sciences, Oncology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3047549
ISBN:	0493620397

Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer.
Drouin, Jacqueline.

Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer. - 142 p.

Adviser: Donald Marcotte.

Thesis (Ph.D.)--Wayne State University, 2002.

Aerobic exercise is associated with improvements in health status however, little is known about its effect during radiation treatment. The purpose of this study was to measure the effects of moderate intensity aerobic exercise training on physical function, body composition, fatigue, mood, immune parameters, and oxidative stress in females undergoing radiation treatment for breast cancer. Following approval by the Human Investigation Committees at Wayne State University and the Karmanos Cancer Institute, 23 females (50.0 ± 8.2 years old) with breast cancer (Stage 0–III) agreed to participate in this study. Participants signed informed consent and were randomly assigned to a moderate intensity aerobic exercise group (AE) or a placebo-stretching group (PS). The AE group performed self-monitored walking, at 50–70% of their maximal heart rate on 3–5 days per week during a 7-week radiation regimen. Measurements were performed one-week before and one-week after the radiation treatments. 21 subjects completed the study, 13 in the AE group and 8 in the PS group. Physical function was measured by peak oxygen consumption (VO2 peak), and grip strength by dynamometry. Fatigue was measured on the Revised-Piper Fatigue Scale and mood by the Profile of Mood States. Body composition was examined by skin caliper technique, body mass and body mass index (BMI). Immune parameters were measured by CD4+ and CD8+ counts and Natural Killer Cell Activity, and oxidative stress by 8-Isoprostane analysis. Following treatment, the Wilcoxan Signed Rank Test revealed a significant improvement in the AE group, but not in the PS group, on VO2 peak (p = .00), skin caliper measures (p = .00), body mass (p = .00), and BMI (p = .00). Immune parameters declined in both groups but final values were not significantly different between groups. Fatigue, mood, and grip strength improved modestly but not significantly in both groups while oxidative stress declined non-significantly in both groups. This study supports moderate intensity aerobic exercise training as a means to improve physical function and body composition during radiation treatment for breast cancer. Additionally, immune parameters and oxidative stress values were not further compromised in the exercise group compared with the placebo group.

ISBN: 0493620397Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer.
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245 1 0 $a Aerobic exercise training effects on physical function, fatigue and mood, immune status, and oxidative stress in subjects undergoing radiation treatment for breast cancer.
300 $a 142 p.
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502 $a Thesis (Ph.D.)--Wayne State University, 2002.
520 $a Aerobic exercise is associated with improvements in health status however, little is known about its effect during radiation treatment. The purpose of this study was to measure the effects of moderate intensity aerobic exercise training on physical function, body composition, fatigue, mood, immune parameters, and oxidative stress in females undergoing radiation treatment for breast cancer. Following approval by the Human Investigation Committees at Wayne State University and the Karmanos Cancer Institute, 23 females (50.0 ± 8.2 years old) with breast cancer (Stage 0–III) agreed to participate in this study. Participants signed informed consent and were randomly assigned to a moderate intensity aerobic exercise group (AE) or a placebo-stretching group (PS). The AE group performed self-monitored walking, at 50–70% of their maximal heart rate on 3–5 days per week during a 7-week radiation regimen. Measurements were performed one-week before and one-week after the radiation treatments. 21 subjects completed the study, 13 in the AE group and 8 in the PS group. Physical function was measured by peak oxygen consumption (VO2 peak), and grip strength by dynamometry. Fatigue was measured on the Revised-Piper Fatigue Scale and mood by the Profile of Mood States. Body composition was examined by skin caliper technique, body mass and body mass index (BMI). Immune parameters were measured by CD4+ and CD8+ counts and Natural Killer Cell Activity, and oxidative stress by 8-Isoprostane analysis. Following treatment, the Wilcoxan Signed Rank Test revealed a significant improvement in the AE group, but not in the PS group, on VO2 peak (p = .00), skin caliper measures (p = .00), body mass (p = .00), and BMI (p = .00). Immune parameters declined in both groups but final values were not significantly different between groups. Fatigue, mood, and grip strength improved modestly but not significantly in both groups while oxidative stress declined non-significantly in both groups. This study supports moderate intensity aerobic exercise training as a means to improve physical function and body composition during radiation treatment for breast cancer. Additionally, immune parameters and oxidative stress values were not further compromised in the exercise group compared with the placebo group.
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