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Leptin-cholecystokinin synergy in th...

Matson, Claire A.

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Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake./
Author:	Matson, Claire A.
Description:	432 p.
Notes:	Chair: Robert C. Ritter.
Contained By:	Dissertation Abstracts International61-10B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9988973
ISBN:	0599962275

Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake.
Matson, Claire A.

Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake. - 432 p.

Chair: Robert C. Ritter.

Thesis (Ph.D.)--Washington State University, 2000.

Leptin, the product of the obese gene, reduces food intake and body weight in rats and mice, while administration of the gut-peptide cholecystokinin (CCK) reduces meal size but not body weight. In the current experiments we report that repeated daily combination of either bolus or chronically infused intracerebroventricular (ICV) leptin and bolus intraperitoneal (IP) CCK results in significantly greater loss of body weight than does leptin alone. In other words, CCK enhances the body weight reducing effects of leptin. However, leptin plus CCK treatment does not always synergistically reduce the size of individual 30-min. sucrose meals during this period, and the effect of leptin-CCK combination on daily chow intake, while significant, is small compared to the robust effects on body weight loss. This synergistic effect on body weight loss depends upon a peripheral action of CCK mediated by CCKA receptors, and a central action of leptin. These data suggest a previously unsuspected role for CCK in body weight regulation that may not depend entirely on reduction of feeding behavior, and suggest a strategy for enhancing the effects of leptin in obese individuals.

ISBN: 0599962275Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake.
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100 1 $a Matson, Claire A. $3 1252903
245 1 0 $a Leptin-cholecystokinin synergy in the regulation of body weight and the control of food intake.
300 $a 432 p.
500 $a Chair: Robert C. Ritter.
500 $a Source: Dissertation Abstracts International, Volume: 61-10, Section: B, page: 5174.
502 $a Thesis (Ph.D.)--Washington State University, 2000.
520 $a Leptin, the product of the obese gene, reduces food intake and body weight in rats and mice, while administration of the gut-peptide cholecystokinin (CCK) reduces meal size but not body weight. In the current experiments we report that repeated daily combination of either bolus or chronically infused intracerebroventricular (ICV) leptin and bolus intraperitoneal (IP) CCK results in significantly greater loss of body weight than does leptin alone. In other words, CCK enhances the body weight reducing effects of leptin. However, leptin plus CCK treatment does not always synergistically reduce the size of individual 30-min. sucrose meals during this period, and the effect of leptin-CCK combination on daily chow intake, while significant, is small compared to the robust effects on body weight loss. This synergistic effect on body weight loss depends upon a peripheral action of CCK mediated by CCKA receptors, and a central action of leptin. These data suggest a previously unsuspected role for CCK in body weight regulation that may not depend entirely on reduction of feeding behavior, and suggest a strategy for enhancing the effects of leptin in obese individuals.
590 $a School code: 0251.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Chemistry, Biochemistry. $3 1017722
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