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Effects of high-load eccentric exerc...

Prisby, Rhonda Dianne.

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Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading./
Author:	Prisby, Rhonda Dianne.
Description:	164 p.
Notes:	Director: Arnold Nelson.
Contained By:	Dissertation Abstracts International63-08B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3063071
ISBN:	0493818200

Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading.
Prisby, Rhonda Dianne.

Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading. - 164 p.

Director: Arnold Nelson.

Thesis (Ph.D.)--Louisiana State University and Agricultural & Mechanical College, 2002.

<italic>Purpose</italic>. This investigation evaluated the effects of a high-load (50% body weight) eccentric exercise training protocol on reloading myofibrillar damage in soleus (SOL) and extensor digitorum longus (EDL) muscles in rats following 7 days (d) of hindlimb suspension unloading (HSU). <italic>Methods</italic>. 48 female Sprague-Dawley rats were randomly stratified to four experimental groups; exercise + hindlimb suspension unloading (ExHSU), hindlimb suspension unloading (HSU), exercise (Ex) and control (C). The ExHSU and Ex groups underwent a high-load eccentric exercise protocol for &sim;2.5 weeks. Following exercise training, the ExHSU and HSU groups underwent 7 d of hindlimb suspension unloading and a subsequent 16–19 h reloading period. ANOVA was used to determine significance between groups for the following variables: body weight (BW) across time, BW at sacrifice, Glucose-6-phosphate dehydrogenase (G-6-PDH) activity, fiber area, fiber area to body-weight ratio, % myofibrillar damage, SOL and EDL wet, dry and wet-weight to body-weight ratios, % interstitial area, adrenal weights and adrenal weight to body-weight ratios, tibia lengths and tibia bone mineral content. <italic> Results</italic>. ANOVA revealed no significant differences (<italic>p</italic> > .10) between the ExHSU and HSU groups for BW at sacrifice, fiber area, fiber area to body-weight ratio, SOL and EDL wet, dry and wet-weight to body-weight ratios, adrenal weights and adrenal weight to body-weight ratios and tibia lengths and bone mineral content. Yet a post analysis t-test revealed a significantly higher % of myofibrillar damage in the HSU vs. the ExHSU group. Further, G-6-PDH activity and % interstitial area approached significance (<italic>p</italic> = 0.134 and <italic>p</italic> = 0.152, respectively). <italic>Conclusions </italic>. The high-load eccentric exercise training protocol prior to HSU attenuated the % of myofibrillar damage during reloading. Further, the % of interstitial area and G-6-PDH activity tended to be smaller in the ExHSU group vs. the HSU group. Therefore, eccentric exercise prior to HSU may elicit a repeated bout effect and attenuate the amount damage incurred by the muscle during reloading. Additionally, this investigation was the first to demonstrate increased G-6-PDH activity with reloading myofibrillar damage.

ISBN: 0493818200Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading.
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035 $a (UnM)AAI3063071
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100 1 $a Prisby, Rhonda Dianne. $3 1252881
245 1 0 $a Effects of high-load eccentric exercise training on rat soleus muscle myofibrillar disruption following one-week of hindlimb suspension unloading and subsequent reloading.
300 $a 164 p.
500 $a Director: Arnold Nelson.
500 $a Source: Dissertation Abstracts International, Volume: 63-08, Section: B, page: 3538.
502 $a Thesis (Ph.D.)--Louisiana State University and Agricultural & Mechanical College, 2002.
520 $a <italic>Purpose</italic>. This investigation evaluated the effects of a high-load (50% body weight) eccentric exercise training protocol on reloading myofibrillar damage in soleus (SOL) and extensor digitorum longus (EDL) muscles in rats following 7 days (d) of hindlimb suspension unloading (HSU). <italic>Methods</italic>. 48 female Sprague-Dawley rats were randomly stratified to four experimental groups; exercise + hindlimb suspension unloading (ExHSU), hindlimb suspension unloading (HSU), exercise (Ex) and control (C). The ExHSU and Ex groups underwent a high-load eccentric exercise protocol for &sim;2.5 weeks. Following exercise training, the ExHSU and HSU groups underwent 7 d of hindlimb suspension unloading and a subsequent 16–19 h reloading period. ANOVA was used to determine significance between groups for the following variables: body weight (BW) across time, BW at sacrifice, Glucose-6-phosphate dehydrogenase (G-6-PDH) activity, fiber area, fiber area to body-weight ratio, % myofibrillar damage, SOL and EDL wet, dry and wet-weight to body-weight ratios, % interstitial area, adrenal weights and adrenal weight to body-weight ratios, tibia lengths and tibia bone mineral content. <italic> Results</italic>. ANOVA revealed no significant differences (<italic>p</italic> > .10) between the ExHSU and HSU groups for BW at sacrifice, fiber area, fiber area to body-weight ratio, SOL and EDL wet, dry and wet-weight to body-weight ratios, adrenal weights and adrenal weight to body-weight ratios and tibia lengths and bone mineral content. Yet a post analysis t-test revealed a significantly higher % of myofibrillar damage in the HSU vs. the ExHSU group. Further, G-6-PDH activity and % interstitial area approached significance (<italic>p</italic> = 0.134 and <italic>p</italic> = 0.152, respectively). <italic>Conclusions </italic>. The high-load eccentric exercise training protocol prior to HSU attenuated the % of myofibrillar damage during reloading. Further, the % of interstitial area and G-6-PDH activity tended to be smaller in the ExHSU group vs. the HSU group. Therefore, eccentric exercise prior to HSU may elicit a repeated bout effect and attenuate the amount damage incurred by the muscle during reloading. Additionally, this investigation was the first to demonstrate increased G-6-PDH activity with reloading myofibrillar damage.
590 $a School code: 0107.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Recreation. $3 1018003
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710 2 0 $a Louisiana State University and Agricultural & Mechanical College. $3 783779
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