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The role of nitric oxide synthase in...

Smith, Lori Wynne.

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The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload./
Author:	Smith, Lori Wynne.
Description:	97 p.
Notes:	Adviser: David Criswell.
Contained By:	Masters Abstracts International40-02.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1406069
ISBN:	0493349197

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.
Smith, Lori Wynne.

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload. - 97 p.

Adviser: David Criswell.

Thesis (M.S.)--Texas Woman's University, 2001.

This study determined the necessity of nitric oxide (NO) for hypertrophy and fiber type transition in overloaded (OL) skeletal muscle. Endogenous NO production was blocked by N-nitro-L-arginine methyl ester (L-NAME; 0.75 mg/ml; &sim;100mg/kg/day) in drinking water. Thirty-eight female Sprague-Dawley rats (&sim;250g) were randomly divided into four groups: Control-NonOL, Control-OL, L-NAME-NonOL, and L-NAME-OL. Chronic overload of the plantaris was induced bilaterally by surgical removal of the gastrocnemius and soleus. L-NAME treatment began 24 hrs before surgery and continued through the 14-day OL period. Although OL induced hypertrophy in both Control (+80%) and L-NAME (+48%) conditions (P < 0.05), mean plantaris mass in the L-NAME-OL group was lower (P < 0.05) than the Control-OL group. SDS-PAGE analysis of myosin heavy chain (MHC) composition indicated an (P < 0.05) OL-effect in the Control rats. Specifically, the mean proportion of type I MHC increased 6% (P < 0.05) while type IIb MHC decreased &sim;9% (P < 0.05). No significant OL effects on MHC profile were observed in the L-NAME rats. These data support a role of NO in overload-induced skeletal muscle hypertrophy and fiber type transition.

ISBN: 0493349197Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.
LDR:02092nam 2200277 a 45 001 929320
005 20110427
008 110427s2001 eng d
020 $a 0493349197
035 $a (UnM)AAI1406069
035 $a AAI1406069
040 $a UnM $c UnM
100 1 $a Smith, Lori Wynne. $3 1252804
245 1 0 $a The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.
300 $a 97 p.
500 $a Adviser: David Criswell.
500 $a Source: Masters Abstracts International, Volume: 40-02, page: 0449.
502 $a Thesis (M.S.)--Texas Woman's University, 2001.
520 $a This study determined the necessity of nitric oxide (NO) for hypertrophy and fiber type transition in overloaded (OL) skeletal muscle. Endogenous NO production was blocked by N-nitro-L-arginine methyl ester (L-NAME; 0.75 mg/ml; &sim;100mg/kg/day) in drinking water. Thirty-eight female Sprague-Dawley rats (&sim;250g) were randomly divided into four groups: Control-NonOL, Control-OL, L-NAME-NonOL, and L-NAME-OL. Chronic overload of the plantaris was induced bilaterally by surgical removal of the gastrocnemius and soleus. L-NAME treatment began 24 hrs before surgery and continued through the 14-day OL period. Although OL induced hypertrophy in both Control (+80%) and L-NAME (+48%) conditions (P < 0.05), mean plantaris mass in the L-NAME-OL group was lower (P < 0.05) than the Control-OL group. SDS-PAGE analysis of myosin heavy chain (MHC) composition indicated an (P < 0.05) OL-effect in the Control rats. Specifically, the mean proportion of type I MHC increased 6% (P < 0.05) while type IIb MHC decreased &sim;9% (P < 0.05). No significant OL effects on MHC profile were observed in the L-NAME rats. These data support a role of NO in overload-induced skeletal muscle hypertrophy and fiber type transition.
590 $a School code: 0925.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0433
690 $a 0487
710 2 0 $a Texas Woman's University. $3 1017666
773 0 $t Masters Abstracts International $g 40-02.
790 $a 0925
790 1 0 $a Criswell, David, $e advisor
791 $a M.S.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1406069