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Development of novel biodegradable a...

Woo, Gregory Lu-Yuen.

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Development of novel biodegradable antimicrobial polymers for biomaterials applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development of novel biodegradable antimicrobial polymers for biomaterials applications./
Author:	Woo, Gregory Lu-Yuen.
Description:	154 p.
Notes:	Adviser: J. P. Santerre.
Contained By:	Masters Abstracts International38-01.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ40915
ISBN:	0612409155

Development of novel biodegradable antimicrobial polymers for biomaterials applications.
Woo, Gregory Lu-Yuen.

Development of novel biodegradable antimicrobial polymers for biomaterials applications. - 154 p.

Adviser: J. P. Santerre.

Thesis (M.A.Sc.)--University of Toronto (Canada), 1998.

Bacterial infection is a frequent complication associated with the use of medical devices. Antimicrobial agents have been incorporated into or applied directly onto the surfaces of devices to combat infection. This thesis will assess the feasibility of using a novel biodegradable polymer to release antibiotic drugs in response to inflammatory related enzymes. A series of biodegradable drug polymers were synthesized using diisocyanates, oligomeric compounds, and an antibiotic, ciprofloxacin. The drug polymers were characterized by gel permeation chromatography (GPC), and elemental analysis. Biodegradation studies were carried out by incubating the polymers with solutions of cholesterol esterase (CE). Degradation was assessed by high performance liquid chromatography (HPLC), mass spectrometry (MS) and radiolabel release. Subsequently, the activity of the released antibiotic was assessed against a clinical isolate of Pseudomonas aeruginosa. For one of the polymer formulations, the release of ciprofloxacin was approximately two-fold higher in the presence of enzyme as compared to buffer alone. Another formulation using a different diisocyanate showed the release of multiple degradation products. The results of this study suggest that these novel antimicrobial polymers or similar analogs show good potential for use in the control of medical device associated infections.

ISBN: 0612409155Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Development of novel biodegradable antimicrobial polymers for biomaterials applications.
LDR:02263nam 2200277 a 45 001 928349
005 20110426
008 110426s1998 eng d
020 $a 0612409155
035 $a (UnM)AAIMQ40915
035 $a AAIMQ40915
040 $a UnM $c UnM
100 1 $a Woo, Gregory Lu-Yuen. $3 1251810
245 1 0 $a Development of novel biodegradable antimicrobial polymers for biomaterials applications.
300 $a 154 p.
500 $a Adviser: J. P. Santerre.
500 $a Source: Masters Abstracts International, Volume: 38-01, page: 0235.
502 $a Thesis (M.A.Sc.)--University of Toronto (Canada), 1998.
520 $a Bacterial infection is a frequent complication associated with the use of medical devices. Antimicrobial agents have been incorporated into or applied directly onto the surfaces of devices to combat infection. This thesis will assess the feasibility of using a novel biodegradable polymer to release antibiotic drugs in response to inflammatory related enzymes. A series of biodegradable drug polymers were synthesized using diisocyanates, oligomeric compounds, and an antibiotic, ciprofloxacin. The drug polymers were characterized by gel permeation chromatography (GPC), and elemental analysis. Biodegradation studies were carried out by incubating the polymers with solutions of cholesterol esterase (CE). Degradation was assessed by high performance liquid chromatography (HPLC), mass spectrometry (MS) and radiolabel release. Subsequently, the activity of the released antibiotic was assessed against a clinical isolate of Pseudomonas aeruginosa. For one of the polymer formulations, the release of ciprofloxacin was approximately two-fold higher in the presence of enzyme as compared to buffer alone. Another formulation using a different diisocyanate showed the release of multiple degradation products. The results of this study suggest that these novel antimicrobial polymers or similar analogs show good potential for use in the control of medical device associated infections.
590 $a School code: 0779.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0541
690 $a 0572
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 38-01.
790 $a 0779
790 1 0 $a Santerre, J. P., $e advisor
791 $a M.A.Sc.
792 $a 1998
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ40915