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Studies on chromosome segregation an...

Badrinath, Ananthkumar Sengamedu.

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Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans./
Author:	Badrinath, Ananthkumar Sengamedu.
Description:	87 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-07, Section: B, page: 3102.
Contained By:	Dissertation Abstracts International63-07B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3060442
ISBN:	0493761063

Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans.
Badrinath, Ananthkumar Sengamedu.

Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans. - 87 p.

Source: Dissertation Abstracts International, Volume: 63-07, Section: B, page: 3102.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2002.

I have conducted studies that touch upon two aspects of early <italic> Caenorhabditis elegans</italic> (<italic>C. elegans</italic>) development—the completion of meiosis and the establishment of embryonic polarity, both of which ensue shortly after fertilization.

ISBN: 0493761063Subjects--Topical Terms:

1017686
Biology, Cell.

Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans.
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035 $a (UnM)AAI3060442
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040 $a UnM $c UnM
100 1 $a Badrinath, Ananthkumar Sengamedu. $3 1251342
245 1 0 $a Studies on chromosome segregation and establishment of polarity in Caenorhabditis elegans.
300 $a 87 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-07, Section: B, page: 3102.
500 $a Supervisor: John G. White.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2002.
520 $a I have conducted studies that touch upon two aspects of early <italic> Caenorhabditis elegans</italic> (<italic>C. elegans</italic>) development—the completion of meiosis and the establishment of embryonic polarity, both of which ensue shortly after fertilization.
520 $a Separase is a conserved protease required for the dissolution of cohesion between sister-chromatids at the metaphase to anaphase transition. I found that inactivation of the <italic>C. elegans</italic> homolog by mutation interfered with chromatid separation during embryonic mitotic divisions. Interestingly, affected embryos also appeared swollen <italic>in utero</italic> and displayed a complete failure in cell division, which indicated that separase might have roles in addition to its known role in chromosome segregation. Targeted gene inactivation through RNA mediated interference (RNAi) resulted in a stronger phenotype with a complete failure in chromosome segregation during meiosis I. This is the first study to indicate a role for separase in chromosome segregation in meiosis I in a metazoan.
520 $a I compared the pattern of redistribution of a ubiquitous cytoplasmic constituent, mitochondria, in the early embryos of <italic>Caenorhabditis elegans</italic> and <italic>Acrobeloides sp. PS 1146</italic> (<italic>Acrobeloides </italic>), and found them to be dramatically different. These related nematodes share a common early cell lineage, but use different mechanisms to specify the initial antero-posterior axis as well as the order and orientation of cell divisions. In spite of these differences, both species develop into morphologically similar adults. The difference in their mitochondrial redistribution during embryogenesis is an example of a striking evolutionary divergence in a developmental process that ultimately produces similar body-plans.
590 $a School code: 0262.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Zoology. $3 1018632
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690 $a 0379
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710 2 0 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 63-07B.
790 $a 0262
790 1 0 $a White, John G., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3060442