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Identification of novel signaling co...

Xiao, Changchun.

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Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development./
Author:	Xiao, Changchun.
Description:	147 p.
Notes:	Director: Sankar Ghosh.
Contained By:	Dissertation Abstracts International63-03B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3046255
ISBN:	0493605002

Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development.
Xiao, Changchun.

Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development. - 147 p.

Director: Sankar Ghosh.

Thesis (Ph.D.)--Yale University, 2002.

The Toll pathway determines dorsoventral axis of Drosophila embryos and is essential for the antifungal response of adult flies. The mammalian homologs of Toll, Toll-like receptors (TLRs), are required for host defense against microbial infections. The cytoplasmic domain of Interleukin-1 Receptor (IL-1R) shares high homology with those of TLRs. IL-1R regulates the inflammatory response, a part of mammalian host defense. TLR and IL-1R signal transduction pathways share common components. Both pathways activate NFκB and AP-1. This thesis describes the identification, characterization, and functional studies of two novel signaling components of the Toll/IL-1R pathway: X and ECSIT. Both components are highly conserved evolutionarily. They play different roles in the Toll/IL-1R signal transduction pathway: ECSIT is an obligatory component for signal relay, whereas X negatively regulates it. Moreover, ECSIT is specific for the Toll/IL-1R pathway, whereas X inhibits other signal transduction pathways too. Mouse gene targeting experiments show that both components are indispensable for early embryo development: ECSIT is crucial for anterior-posterior axis formation and X is required for proper formation and differentiation of mesoderm. Analysis of homozygous null <italic>Ecsit</italic> mutant embryos revealed a possible link between the Toll pathway and the TGFβ pathways and further studies are ongoing to test this hypothesis.

ISBN: 0493605002Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development.
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005 20110425
008 110425s2002 eng d
020 $a 0493605002
035 $a (UnM)AAI3046255
035 $a AAI3046255
040 $a UnM $c UnM
100 1 $a Xiao, Changchun. $3 1251246
245 1 0 $a Identification of novel signaling components of the Toll/IL-1R pathway and their functions in innate immunity and development.
300 $a 147 p.
500 $a Director: Sankar Ghosh.
500 $a Source: Dissertation Abstracts International, Volume: 63-03, Section: B, page: 1254.
502 $a Thesis (Ph.D.)--Yale University, 2002.
520 $a The Toll pathway determines dorsoventral axis of Drosophila embryos and is essential for the antifungal response of adult flies. The mammalian homologs of Toll, Toll-like receptors (TLRs), are required for host defense against microbial infections. The cytoplasmic domain of Interleukin-1 Receptor (IL-1R) shares high homology with those of TLRs. IL-1R regulates the inflammatory response, a part of mammalian host defense. TLR and IL-1R signal transduction pathways share common components. Both pathways activate NFκB and AP-1. This thesis describes the identification, characterization, and functional studies of two novel signaling components of the Toll/IL-1R pathway: X and ECSIT. Both components are highly conserved evolutionarily. They play different roles in the Toll/IL-1R signal transduction pathway: ECSIT is an obligatory component for signal relay, whereas X negatively regulates it. Moreover, ECSIT is specific for the Toll/IL-1R pathway, whereas X inhibits other signal transduction pathways too. Mouse gene targeting experiments show that both components are indispensable for early embryo development: ECSIT is crucial for anterior-posterior axis formation and X is required for proper formation and differentiation of mesoderm. Analysis of homozygous null <italic>Ecsit</italic> mutant embryos revealed a possible link between the Toll pathway and the TGFβ pathways and further studies are ongoing to test this hypothesis.
590 $a School code: 0265.
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0982
710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 63-03B.
790 $a 0265
790 1 0 $a Ghosh, Sankar, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3046255