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Identification and characterization ...

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Identification and characterization of genes that regulate GABA synapses.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Identification and characterization of genes that regulate GABA synapses./
Author:	Vashlishan, Amy Beth.
Description:	150 p.
Notes:	Adviser: Joshua Kaplan.
Contained By:	Dissertation Abstracts International69-04B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3312554
ISBN:	9780549613725

Identification and characterization of genes that regulate GABA synapses.
Vashlishan, Amy Beth.

Identification and characterization of genes that regulate GABA synapses. - 150 p.

Adviser: Joshua Kaplan.

Thesis (Ph.D.)--Harvard University, 2008.

Cognition and behavior depend upon a precise balance of synaptic activity within circuits of interconnected neurons. Inhibitory GABAergic synapses play a critical role in many aspects of circuit development and function and are necessary to maintain this circuit balance. For example, conditions that perturb GABA transmission have been implicated in epilepsy, autism, and schizophrenia. The biological basis of this balance has historically been difficult to study due to the complex circuitry of the mammalian brain.

ISBN: 9780549613725Subjects--Topical Terms:

1017730
Biology, Genetics.

Identification and characterization of genes that regulate GABA synapses.
LDR:02367nmm 2200289 a 45 001 886897
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020 $a 9780549613725
035 $a (UMI)AAI3312554
035 $a AAI3312554
040 $a UMI $c UMI
100 1 $a Vashlishan, Amy Beth. $3 1058614
245 1 0 $a Identification and characterization of genes that regulate GABA synapses.
300 $a 150 p.
500 $a Adviser: Joshua Kaplan.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2081.
502 $a Thesis (Ph.D.)--Harvard University, 2008.
520 $a Cognition and behavior depend upon a precise balance of synaptic activity within circuits of interconnected neurons. Inhibitory GABAergic synapses play a critical role in many aspects of circuit development and function and are necessary to maintain this circuit balance. For example, conditions that perturb GABA transmission have been implicated in epilepsy, autism, and schizophrenia. The biological basis of this balance has historically been difficult to study due to the complex circuitry of the mammalian brain.
520 $a Body muscles at neuromuscular junctions of the nematode C. elegans receive both excitatory and inhibitory neuronal inputs, making this an ideal model system for identifying genes that are needed to maintain circuit balance. We used RNA interference to screen for genes whose inactivation increased the activity of C. elegans body muscles, identifying 90 genes. Using electrophysiological recordings and imaging of excitatory and inhibitory synapses, we determined that several of these genes alter muscle activity by selectively regulating inhibitory transmission. In particular, we identify two humoral pathways and several protein kinases that modulate GABA transmission but have little effect on excitatory transmission at cholinergic neuromuscular junctions. Our data suggest these conserved genes are components of signaling pathways that regulate GABA transmission, and consequently may play a role in epilepsy and other cognitive or psychiatric disorders.
590 $a School code: 0084.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0317
690 $a 0369
710 2 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 69-04B.
790 $a 0084
790 1 0 $a Kaplan, Joshua, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3312554