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A nonlinear multicompartmental cochl...

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A nonlinear multicompartmental cochlear model.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A nonlinear multicompartmental cochlear model./
Author:	Lu, Shan.
Description:	151 p.
Notes:	Adviser: Allyn E. Hubbard.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334549
ISBN:	9780549873785

A nonlinear multicompartmental cochlear model.
Lu, Shan.

A nonlinear multicompartmental cochlear model. - 151 p.

Adviser: Allyn E. Hubbard.

Thesis (Ph.D.)--Boston University, 2009.

An active process known as the "cochlear amplifier (CA)" boosts mammalian hearing sensitivity by a hundredfold. This amplification is thought to be due to the outer hair cells (OHCs) electromotility, but the underlying mechanism is still obscure. We studied a new hypothesis that could explain how the CA works, based on results obtained from a nonlinear multicompartment model of the cochlea with OHC piezoelectrical feedback. Unlike the traditional cochlear model, this model includes an additional transmission line: the organ of Corti (OC) fluid flow. The OHC electroanatomical circuit senses the motion of the RL-stereocilia, and feeds back an active force to the hydromechanical system via a piezoelectric element. Therefore, the mechanical loading of the OHC couples bi-directionally with the electrical impedance of the OHC. We also include in the model the fast adaptation of the tension gated channel due to the hair bundle motility.

ISBN: 9780549873785Subjects--Topical Terms:

1017684
Engineering, Biomedical.

A nonlinear multicompartmental cochlear model.
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020 $a 9780549873785
035 $a (UMI)AAI3334549
035 $a AAI3334549
040 $a UMI $c UMI
100 1 $a Lu, Shan. $3 1058283
245 1 2 $a A nonlinear multicompartmental cochlear model.
300 $a 151 p.
500 $a Adviser: Allyn E. Hubbard.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6255.
502 $a Thesis (Ph.D.)--Boston University, 2009.
520 $a An active process known as the "cochlear amplifier (CA)" boosts mammalian hearing sensitivity by a hundredfold. This amplification is thought to be due to the outer hair cells (OHCs) electromotility, but the underlying mechanism is still obscure. We studied a new hypothesis that could explain how the CA works, based on results obtained from a nonlinear multicompartment model of the cochlea with OHC piezoelectrical feedback. Unlike the traditional cochlear model, this model includes an additional transmission line: the organ of Corti (OC) fluid flow. The OHC electroanatomical circuit senses the motion of the RL-stereocilia, and feeds back an active force to the hydromechanical system via a piezoelectric element. Therefore, the mechanical loading of the OHC couples bi-directionally with the electrical impedance of the OHC. We also include in the model the fast adaptation of the tension gated channel due to the hair bundle motility.
520 $a The results from this study show that, the CA function is a consequence of a combination of forces on the reticular lamina (RL) and the basilar membrane (BM) coming from both local OHCs and a pressure wave that propagates in the fluid-filled spaces of OC. It suggests that the OC flow observed experimentally is essential to the cochlear active response. We also found that the OHC hair bundle fast adaptation moderates the phase of the active force generated by the OHC, while the OHC somatic motility controls the gain of the active force. The simulation results demonstrate that a piezoelectric OHC can at least partially compensate the OHC low-pass filtering due to the cell wall capacitance, which is a long standing issue in the hearing research area.
520 $a Distortion product (DP) otoacoustic emissions (DPOAE) are sounds generated by the inner ear when stimulated with two primary tones. How DPs propagate from the generation site to the stapes has been a major topic in recent years. The model results support the theory that the DPOAE are transmitted back to the stapes via a reverse traveling wave, which starts to dominate from a place that is basal to the f2 place, not from the DP place.
590 $a School code: 0017.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Health Sciences, Audiology. $3 1018138
690 $a 0300
690 $a 0541
690 $a 0544
710 2 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0017
790 1 0 $a Hubbard, Allyn E., $e advisor
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334549