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Design and synthesis of small molecu...

Georgia Institute of Technology.

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Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery./
Author:	Chen, Po-Chih.
Description:	458 p.
Notes:	Adviser: Adegboyega (Yomi) Oyelere.
Contained By:	Dissertation Abstracts International70-06B.
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3364192
ISBN:	9781109244946

Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery.
Chen, Po-Chih.

Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery. - 458 p.

Adviser: Adegboyega (Yomi) Oyelere.

Thesis (Ph.D.)--Georgia Institute of Technology, 2009.

Histone deacetylase (HDAC) inhibition is an emerging novel therapeutic strategy in cancer therapy. HDAC inhibitors (HDACi) have shown ability to block angiogenesis and cell cycling, as well as initiate differentiation and apoptosis. In fact, suberoylanilide hydroxamic acid (SAHA) is the first in the class of HDACi approved by the FDA for the treatment of cutaneous T cell lymphoma. On the other hand, there is a sustained interest in the use of gold nanoparticles (AuNPs) for various cancer diagnostic and therapeutic applications - bioimaging, drug delivery, and binary therapy techniques such as photodynamic and photothermal therapies. This interest in AuNPs is facilitated by favorable attributes such as case of fabrication, bioconjugation and biocompatibility, and unique optical and electronic properties. However, HDACi- and AuNPs- based antitumor agents are plagued with problems common to all chemotherapeutic agents such as lack of selectivity, which often results in systemic toxicity. Therefore, availability of a methodology to selectively deliver AuNPs and HDACi to cancer cells will significantly improve their therapeutic indices and lead to the identification of novel agents for use in diagnostic imaging and targeted cancer therapy applications.

ISBN: 9781109244946Subjects--Topical Terms:

516206
Chemistry, Organic.

Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery.
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245 1 0 $a Design and synthesis of small molecules and nanoparticle conjugates for cell type-selective delivery.
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500 $a Source: Dissertation Abstracts International, Volume: 70-06, Section: B, page: .
502 $a Thesis (Ph.D.)--Georgia Institute of Technology, 2009.
520 $a Histone deacetylase (HDAC) inhibition is an emerging novel therapeutic strategy in cancer therapy. HDAC inhibitors (HDACi) have shown ability to block angiogenesis and cell cycling, as well as initiate differentiation and apoptosis. In fact, suberoylanilide hydroxamic acid (SAHA) is the first in the class of HDACi approved by the FDA for the treatment of cutaneous T cell lymphoma. On the other hand, there is a sustained interest in the use of gold nanoparticles (AuNPs) for various cancer diagnostic and therapeutic applications - bioimaging, drug delivery, and binary therapy techniques such as photodynamic and photothermal therapies. This interest in AuNPs is facilitated by favorable attributes such as case of fabrication, bioconjugation and biocompatibility, and unique optical and electronic properties. However, HDACi- and AuNPs- based antitumor agents are plagued with problems common to all chemotherapeutic agents such as lack of selectivity, which often results in systemic toxicity. Therefore, availability of a methodology to selectively deliver AuNPs and HDACi to cancer cells will significantly improve their therapeutic indices and lead to the identification of novel agents for use in diagnostic imaging and targeted cancer therapy applications.
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