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Continuous time-of-flight mass spect...

Stanford University.

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Continuous time-of-flight mass spectrometric imaging of fragmented ions.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Continuous time-of-flight mass spectrometric imaging of fragmented ions./
Author:	Yoon, Oh Kyu.
Description:	287 p.
Notes:	Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6071.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3332958
ISBN:	9780549850663

Continuous time-of-flight mass spectrometric imaging of fragmented ions.
Yoon, Oh Kyu.

Continuous time-of-flight mass spectrometric imaging of fragmented ions. - 287 p.

Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6071.

Thesis (Ph.D.)--Stanford University, 2008.

I expect Im-HT-TOFMS and HT-IKES to be powerful tools for identifying and probing time-dependent chemical processes of analyte mixtures with applications in stopped-flow solution kinetics and fast chromatography.

ISBN: 9780549850663Subjects--Topical Terms:

586156
Chemistry, Analytical.

Continuous time-of-flight mass spectrometric imaging of fragmented ions.
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020 $a 9780549850663
035 $a (UMI)AAI3332958
035 $a AAI3332958
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100 1 $a Yoon, Oh Kyu. $3 1043570
245 1 0 $a Continuous time-of-flight mass spectrometric imaging of fragmented ions.
300 $a 287 p.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6071.
502 $a Thesis (Ph.D.)--Stanford University, 2008.
520 $a I expect Im-HT-TOFMS and HT-IKES to be powerful tools for identifying and probing time-dependent chemical processes of analyte mixtures with applications in stopped-flow solution kinetics and fast chromatography.
520 $a This thesis describes the implementation, characterization, and theoretical analyses of imaging Hadamard transform time-of-flight mass spectrometry (Im-HT-TOFMS). This new technique is based on pseudorandom ion beam modulation and three-dimensional ion imaging, and it provides mass spectra at every "pixel" of a two-dimensional image with 100% duty cycle. This thesis is organized according to three development stages of Im-HT-TOFMS.
520 $a The first stage is the two-channel Hadamard transform (HT) time-of-flight mass spectrometry (TOFMS). Although TOFMS offers high sensitivity and mass resolution with pulsed ion sources, it is inherently a pulsed technique and efficient coupling to a continuous ion source presents a technical challenge. Two-channel HT-TOFMS is a multiplexing strategy to achieve very high efficiency through ion beam modulation according a pseudorandom binary sequence. Efficiency close to 100% is achieved using a two-channel detector by simultaneously detecting both states of the binary modulation. The implementation of the technique and theoretical analysis of various figures of merit are presented and discussed. Also, Bradbury-Nielsen gate and a double-stage reflectron, which are two important components of the technique, are described. Although 100% efficiency was possible using the two-channel HT-TOFMS, this was often challenging in practice due to the difficulty of matching the ion beam size and deflection angles to the detector dimensions.
520 $a The next stage of development is to employ a three-dimensional imaging detector that can record the positions x, y and flight time t of every ion arrival event. The implementation and characterization of the new Im-HT-TOFMS are described. The technique always has a duty cycle of 100%, and its enhanced peak height precision compared to conventional linear TOFMS is demonstrated. It also has the capability of producing a mass spectrum for every "pixel" of a two-dimensional image of the ion beam. By spatially dispersing different chemical or physical processes, additional information can be obtained. This is demonstrated by imaging the fragmented ions that underwent surface-induced dissociation and post-source decay.
520 $a The final development stage is to modulate the fragmentation process using a laser or an electron gun and to measure both the flight time and kinetic energy of the ions. This new technique termed Hadamard transform ion kinetic energy spectrometry (HT-IKES) can be used to provide tandem mass spectra of a mixture of analytes simultaneously. The design principles of HT-IKES are presented.
590 $a School code: 0212.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Engineering, Electronics and Electrical. $3 626636
690 $a 0486
690 $a 0494
690 $a 0544
710 2 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0212
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3332958