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Methylammonium formate as a mobile p...

Miami University.

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Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography./
Author:	Grossman, Shau.
Description:	123 p.
Notes:	Adviser: Neil D. Danielson.
Contained By:	Masters Abstracts International47-01.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1457971
ISBN:	9780549723899

Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography.
Grossman, Shau.

Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography. - 123 p.

Adviser: Neil D. Danielson.

Thesis (M.S.)--Miami University, 2008.

This study focuses on the synthesis and the characterization of the room temperature ionic liquid methylammonium formate (MAF) and its use as an organic solvent replacement for the mobile phase in liquid chromatography. Spectroscopic characterization as well as measurements of physical properties are determined and compared to previously studied alkylammonium formate ionic liquids. Our chromatographic evidence has shown that MAF is a good silanol suppressor resulting in better peak shape and separation efficiency than methanol as a mobile phase modifier when using C18-based silica columns. The preliminary studies using MAF as a mobile phase modifier or additive for pharmaceutical applications using LC-MS methods have shown promising results. The fluorescence studies using cytochrome C as the test compound in five different organic solvents has identified MAF as the least denaturing compared with other solvents including dimethyl sulfoxide, N-methylformamide, methanol, and acetonitrile.

ISBN: 9780549723899Subjects--Topical Terms:

586156
Chemistry, Analytical.

Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography.
LDR:01847nmm 2200265 a 45 001 867361
005 20100804
008 100804s2008 ||||||||||||||||| ||eng d
020 $a 9780549723899
035 $a (UMI)AAI1457971
035 $a AAI1457971
040 $a UMI $c UMI
100 1 $a Grossman, Shau. $3 1036090
245 1 0 $a Methylammonium formate as a mobile phase modifier for reversed phase liquid chromatography.
300 $a 123 p.
500 $a Adviser: Neil D. Danielson.
500 $a Source: Masters Abstracts International, Volume: 47-01, page: 0364.
502 $a Thesis (M.S.)--Miami University, 2008.
520 $a This study focuses on the synthesis and the characterization of the room temperature ionic liquid methylammonium formate (MAF) and its use as an organic solvent replacement for the mobile phase in liquid chromatography. Spectroscopic characterization as well as measurements of physical properties are determined and compared to previously studied alkylammonium formate ionic liquids. Our chromatographic evidence has shown that MAF is a good silanol suppressor resulting in better peak shape and separation efficiency than methanol as a mobile phase modifier when using C18-based silica columns. The preliminary studies using MAF as a mobile phase modifier or additive for pharmaceutical applications using LC-MS methods have shown promising results. The fluorescence studies using cytochrome C as the test compound in five different organic solvents has identified MAF as the least denaturing compared with other solvents including dimethyl sulfoxide, N-methylformamide, methanol, and acetonitrile.
590 $a School code: 0126.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 $a Miami University. $3 1017534
773 0 $t Masters Abstracts International $g 47-01.
790 $a 0126
790 1 0 $a Danielson, Neil D., $e advisor
791 $a M.S.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1457971