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Biomedical applications of carbon na...

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Biomedical applications of carbon nanotubes.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Biomedical applications of carbon nanotubes./
Author:	Liu, Zhuang.
Description:	215 p.
Notes:	Adviser: Hongjie Dai.
Contained By:	Dissertation Abstracts International70-01B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3343857
ISBN:	9780549989806

Biomedical applications of carbon nanotubes.
Liu, Zhuang.

Biomedical applications of carbon nanotubes. - 215 p.

Adviser: Hongjie Dai.

Thesis (Ph.D.)--Stanford University, 2009.

Nano-biotechnology is a multidisciplinary field that bridges physical sciences with biological sciences via chemical tools. Carbon nanotubes with small sizes, unique one dimensional aromatic structure, and interesting inherent physical, especially optical, properties, have shown promise in biology and medicine. This thesis is a comprehensive study of using single walled carbon nanotubes (SWNT) for in vitro and in vivo biomedical applications. In vitro siRNA delivery by SWNTs into 'hard-to-transfect' cells is reported. Drug loading on functionalized SWNTs by supramolecular chemistry is developed for targeted delivery of aromatic cancer drugs to specific types of cancer cells. Next, in vivo biodistribution of SWNTs is monitored by a radiolabeling methodology, as well as ex-vivo Raman spectroscopy. The latter provides long-term fate and excretion information of SWNTs in mice. It is found that the surface chemistry of SWNTs largely governs their in vivo behaviors. Prolonged blood circulation, reduced uptake in reticuloendothelial systems (RES) and accelerated excretion are all achieved for SWNTs with superior biocompatible surface coating. Efficient in vivo tumor targeting is also realized by conjugating a targeting peptide to biocompatible SWNTs. After those fundamental explorations, in vivo cancer treatment by SWNT delivery is validated in xenograft mouse models with two chemotherapy drugs, paclitaxel and doxorubicin, loaded on nanotubes in two separate studies. Furthermore, isotope composition-dependent Raman spectroscopy signatures of SWNTs are used for multiple color Raman imaging. In addition to SWNTs, a novel carbon based nanomaterial, nano-graphene oxide, is synthesized and used for drug loading and delivery. Taken together, carbon nanotubes and related nano-biotechnologies are likely to provide new opportunities for challenging problems in biomedicine such as cancer treatment and imaging.

ISBN: 9780549989806Subjects--Topical Terms:

1017681
Biophysics, Medical.

Biomedical applications of carbon nanotubes.
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008 100720s2009 ||||||||||||||||| ||eng d
020 $a 9780549989806
035 $a (UMI)AAI3343857
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040 $a UMI $c UMI
100 1 $a Liu, Zhuang. $3 1030260
245 1 0 $a Biomedical applications of carbon nanotubes.
300 $a 215 p.
500 $a Adviser: Hongjie Dai.
500 $a Source: Dissertation Abstracts International, Volume: 70-01, Section: B, page: 0318.
502 $a Thesis (Ph.D.)--Stanford University, 2009.
520 $a Nano-biotechnology is a multidisciplinary field that bridges physical sciences with biological sciences via chemical tools. Carbon nanotubes with small sizes, unique one dimensional aromatic structure, and interesting inherent physical, especially optical, properties, have shown promise in biology and medicine. This thesis is a comprehensive study of using single walled carbon nanotubes (SWNT) for in vitro and in vivo biomedical applications. In vitro siRNA delivery by SWNTs into 'hard-to-transfect' cells is reported. Drug loading on functionalized SWNTs by supramolecular chemistry is developed for targeted delivery of aromatic cancer drugs to specific types of cancer cells. Next, in vivo biodistribution of SWNTs is monitored by a radiolabeling methodology, as well as ex-vivo Raman spectroscopy. The latter provides long-term fate and excretion information of SWNTs in mice. It is found that the surface chemistry of SWNTs largely governs their in vivo behaviors. Prolonged blood circulation, reduced uptake in reticuloendothelial systems (RES) and accelerated excretion are all achieved for SWNTs with superior biocompatible surface coating. Efficient in vivo tumor targeting is also realized by conjugating a targeting peptide to biocompatible SWNTs. After those fundamental explorations, in vivo cancer treatment by SWNT delivery is validated in xenograft mouse models with two chemotherapy drugs, paclitaxel and doxorubicin, loaded on nanotubes in two separate studies. Furthermore, isotope composition-dependent Raman spectroscopy signatures of SWNTs are used for multiple color Raman imaging. In addition to SWNTs, a novel carbon based nanomaterial, nano-graphene oxide, is synthesized and used for drug loading and delivery. Taken together, carbon nanotubes and related nano-biotechnologies are likely to provide new opportunities for challenging problems in biomedicine such as cancer treatment and imaging.
590 $a School code: 0212.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Chemistry, Physical. $3 560527
690 $a 0494
690 $a 0760
710 2 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 70-01B.
790 $a 0212
790 1 0 $a Dai, Hongjie, $e advisor
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3343857