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Developing microfluidic routes for u...

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Developing microfluidic routes for understanding transport of complex and biological fluids; experimental, numerical and analytical approaches.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Developing microfluidic routes for understanding transport of complex and biological fluids; experimental, numerical and analytical approaches./
Author:	Lee, Jinkee.
Description:	244 p.
Notes:	Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3680.
Contained By:	Dissertation Abstracts International69-06B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3319102
ISBN:	9780549689614

Developing microfluidic routes for understanding transport of complex and biological fluids; experimental, numerical and analytical approaches.
Lee, Jinkee.

Developing microfluidic routes for understanding transport of complex and biological fluids; experimental, numerical and analytical approaches. - 244 p.

Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3680.

Thesis (Ph.D.)--Brown University, 2008.

This dissertation presents experimental, numerical and analytical approaches to understand the transport and microstructure of complex fluids in microfluidic geometries. In the experimental part of this thesis, I present a microfluidic approach to understand the evolution of surfactant mesophases in micro and nano-geometries. A new technique to rapidly the explore the phase diagram of surfactant mesophases using fluorescence microscopy is discussed. The work also explores the role of nano-confinement on the formation of surfactant mesophases using the Small Angle Neutron Scattering (SANS). I also present a new integrated microfluidic chip/cryo-TEM system to visualize rapid structural transitions induced by mixing micellar solutions of surfactants. The experiments show a new dynamical route where aggregates form long cylindrical vesicles which grow into wavy tubular structures and finally transform into vesicles. In addition to the above studies on surfactant systems, I present two more experimental investigations: (1) microfluidic screening of protein folding/unfolding conformations with and without labeling, and (2) measurements of intrinsic viscosities of polymers using a microfluidics platform. In the theoretical part of this thesis, I present Taylor-dispersion analysis of DNA plugs in a continuous flow nucleic acid amplification microchip. The results show an enhanced dispersion by temperature oscillations. It is also shown that insufficient nucleotides concentrations can lead to a complete depletion of NTP at certain axial locations. Lastly, in the numerical part of this thesis, I present transport modeling of microfluidic bio fuel cells. The analysis predicts optimal conditions for operating membraneless bio fuel cells for the maximum production of electricity and minimum consumption of fuel. I conclude this thesis with my recommendations for future work.

ISBN: 9780549689614Subjects--Topical Terms:

1019105
Biophysics, General.

Developing microfluidic routes for understanding transport of complex and biological fluids; experimental, numerical and analytical approaches.
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500 $a Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3680.
502 $a Thesis (Ph.D.)--Brown University, 2008.
520 $a This dissertation presents experimental, numerical and analytical approaches to understand the transport and microstructure of complex fluids in microfluidic geometries. In the experimental part of this thesis, I present a microfluidic approach to understand the evolution of surfactant mesophases in micro and nano-geometries. A new technique to rapidly the explore the phase diagram of surfactant mesophases using fluorescence microscopy is discussed. The work also explores the role of nano-confinement on the formation of surfactant mesophases using the Small Angle Neutron Scattering (SANS). I also present a new integrated microfluidic chip/cryo-TEM system to visualize rapid structural transitions induced by mixing micellar solutions of surfactants. The experiments show a new dynamical route where aggregates form long cylindrical vesicles which grow into wavy tubular structures and finally transform into vesicles. In addition to the above studies on surfactant systems, I present two more experimental investigations: (1) microfluidic screening of protein folding/unfolding conformations with and without labeling, and (2) measurements of intrinsic viscosities of polymers using a microfluidics platform. In the theoretical part of this thesis, I present Taylor-dispersion analysis of DNA plugs in a continuous flow nucleic acid amplification microchip. The results show an enhanced dispersion by temperature oscillations. It is also shown that insufficient nucleotides concentrations can lead to a complete depletion of NTP at certain axial locations. Lastly, in the numerical part of this thesis, I present transport modeling of microfluidic bio fuel cells. The analysis predicts optimal conditions for operating membraneless bio fuel cells for the maximum production of electricity and minimum consumption of fuel. I conclude this thesis with my recommendations for future work.
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650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, General. $3 1020744
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