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Liquid chromatography/mass spectrome...

The Pennsylvania State University.

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Liquid chromatography/mass spectrometric methodologies for metabolomics.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Liquid chromatography/mass spectrometric methodologies for metabolomics./
作者:	Hanley, John C., Jr.
面頁冊數:	298 p.
附註:	Adviser: A. Daniel Jones.
Contained By:	Dissertation Abstracts International67-08B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3229404
ISBN:	9780542809736

Liquid chromatography/mass spectrometric methodologies for metabolomics.
Hanley, John C., Jr.

Liquid chromatography/mass spectrometric methodologies for metabolomics. - 298 p.

Adviser: A. Daniel Jones.

Thesis (Ph.D.)--The Pennsylvania State University, 2006.

The advances described herein will serve to expand the potential of metabolomics and lead the way to fulfilling the goals of functional genomics and systems biology.

ISBN: 9780542809736Subjects--Topical Terms:

586156
Chemistry, Analytical.

Liquid chromatography/mass spectrometric methodologies for metabolomics.
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100 1 $a Hanley, John C., Jr. $3 1028850
245 1 0 $a Liquid chromatography/mass spectrometric methodologies for metabolomics.
300 $a 298 p.
500 $a Adviser: A. Daniel Jones.
500 $a Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4394.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2006.
520 $a The advances described herein will serve to expand the potential of metabolomics and lead the way to fulfilling the goals of functional genomics and systems biology.
520 $a After the establishment of technologies for high-throughout DNA sequencing (genomics), gene expression analysis (transcriptomics) and protein analysis (proteomics), the remaining challenge for functional genomics is wholesale metabolite analysis---metabolomics. The fundamental role of metabolomics is to correlate relative changes in metabolite levels with functional assignments.
520 $a This thesis describes the development of new liquid chromatography-mass spectrometric methodologies for analyzing complex mixtures of analytes with the immediate goal of correlating metabolic and gene expression changes as related to plant defenses. In the process, new internal retention standards were developed for standardizing LC/MS analyses and quantifying metabolites. The unique mass spectrometric fragmentation behavior of a series of phenolic esters was examined as model compounds for secondary plant metabolites. Finally a metabolomics method was established for the analysis of plant extracts by negative mode electrospray ionization mass spectrometry. Quantitative data was collected on over 60 secondary plant metabolites with particular emphasis on plant-insect and plant-pathogen interactions.
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791 $a Ph.D.
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