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Statins, cognition, function and hea...

The Johns Hopkins University.

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Statins, cognition, function and health outcomes in older individuals with and without acute head trauma.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Statins, cognition, function and health outcomes in older individuals with and without acute head trauma./
Author:	Schneider, Eric Bergeim.
Description:	189 p.
Notes:	Adviser: Michelle Carlson.
Contained By:	Dissertation Abstracts International69-12B.
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3339999
ISBN:	9780549939832

Statins, cognition, function and health outcomes in older individuals with and without acute head trauma.
Schneider, Eric Bergeim.

Statins, cognition, function and health outcomes in older individuals with and without acute head trauma. - 189 p.

Adviser: Michelle Carlson.

Thesis (Ph.D.)--The Johns Hopkins University, 2009.

HMG-CoA reductase inhibitors (Statins) have been associated with improved outcomes in animal models of induced brain damage and improved outcomes in epidemiologic studies examining victims of stroke. In each of the above situations, neuro-inflammatory processes can increase physical damage in the brain, which may lead to poorer outcomes. Inflammation in the central nervous system is not limited to acute conditions but is also present in chronic progressive conditions leading to dementia. From the time of Alois Alzheimer, neuro-inflammation has also been implicated as a factor in dementia. At this point, population-based studies are equivocal as to a potential moderating role for Statins in late life dementia.

ISBN: 9780549939832Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Statins, cognition, function and health outcomes in older individuals with and without acute head trauma.
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008 100712s2009 ||||||||||||||||| ||eng d
020 $a 9780549939832
035 $a (UMI)AAI3339999
035 $a AAI3339999
040 $a UMI $c UMI
100 1 $a Schneider, Eric Bergeim. $3 1025313
245 1 0 $a Statins, cognition, function and health outcomes in older individuals with and without acute head trauma.
300 $a 189 p.
500 $a Adviser: Michelle Carlson.
500 $a Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7410.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2009.
520 $a HMG-CoA reductase inhibitors (Statins) have been associated with improved outcomes in animal models of induced brain damage and improved outcomes in epidemiologic studies examining victims of stroke. In each of the above situations, neuro-inflammatory processes can increase physical damage in the brain, which may lead to poorer outcomes. Inflammation in the central nervous system is not limited to acute conditions but is also present in chronic progressive conditions leading to dementia. From the time of Alois Alzheimer, neuro-inflammation has also been implicated as a factor in dementia. At this point, population-based studies are equivocal as to a potential moderating role for Statins in late life dementia.
520 $a Using data collected for the National Study of the Costs and Outcomes of Trauma, this dissertation explores for the first time the relationship between Statin use, survival and functional outcomes in a population of older patients with well-documented head trauma followed for one year. Additionally, using data from the Women's Health and Aging Study II, this dissertation examines Statin use and cognitive change in a cohort of initially healthy older women.
520 $a Among individuals aged 65 and up with multiple traumas including a head injury, Statin use was associated with lower odds of in-hospital death (adjusted O.R. = 0.49, p = 0.04). Among the head trauma survivors, Statin use was associated with higher odds of achieving a good functional recovery at 12 months post injury (adjusted O.R. = 3.54, p = 0.03). In a cohort of initially healthy community-dwelling older women, Statin use was associated with both reduced odds and reduced hazard of developing cognitive impairment on a test of delayed recall (unadjusted O.R. = 0.40, p = 0.05; H.R. = 0.26, p = 0.06) as well as trending toward reduced hazard of developing impairment in executive function (unadjusted H.R. = 0.50, p = 0.07).
520 $a Both studies are limited by sample size and especially by the number of Statin users in each sample; however, the results suggest that Statins may play a role in preserving cognition, function and even life itself in individuals with acute or chronic neuro-inflammatory disorders. Further study is warranted.
590 $a School code: 0098.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Mental Health. $3 1017693
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0347
690 $a 0573
690 $a 0766
710 2 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 69-12B.
790 $a 0098
790 1 0 $a Carlson, Michelle, $e advisor
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3339999