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Type 1 and type 2 diabetes in adulth...

University of California, Berkeley.

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Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health./
Author:	Bronson-Castain, Kevin Wayne.
Description:	242 p.
Notes:	Adviser: Anthony J. Adams.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Health Sciences, Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3331552
ISBN:	9780549834007

Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health.
Bronson-Castain, Kevin Wayne.

Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health. - 242 p.

Adviser: Anthony J. Adams.

Thesis (Ph.D.)--University of California, Berkeley, 2008.

The incidence of diabetes has reached epidemic proportions in the United States. Diabetes affects every major organ system of the human body; of particular focus here are the eye complications. The main purpose of this thesis is to better understand the early pathogenesis of diabetic retinal eye disease in adults and adolescents using multifocal electroretinograms (mfERG), optical coherence tomography (OCT) and digital fundus photography. Early detection of functional, structural and vascular changes will aid in the development of treatments that can prevent permanent damage or further loss of retinal function.

ISBN: 9780549834007Subjects--Topical Terms:

1019445
Health Sciences, Ophthalmology.

Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health.
LDR:03081nam 2200325 a 45 001 858249
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008 100712s2008 ||||||||||||||||| ||eng d
020 $a 9780549834007
035 $a (UMI)AAI3331552
035 $a AAI3331552
040 $a UMI $c UMI
100 1 $a Bronson-Castain, Kevin Wayne. $3 1025292
245 1 0 $a Type 1 and type 2 diabetes in adulthood and adolescence: Focal retinal function, structure and vascular health.
300 $a 242 p.
500 $a Adviser: Anthony J. Adams.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6035.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2008.
520 $a The incidence of diabetes has reached epidemic proportions in the United States. Diabetes affects every major organ system of the human body; of particular focus here are the eye complications. The main purpose of this thesis is to better understand the early pathogenesis of diabetic retinal eye disease in adults and adolescents using multifocal electroretinograms (mfERG), optical coherence tomography (OCT) and digital fundus photography. Early detection of functional, structural and vascular changes will aid in the development of treatments that can prevent permanent damage or further loss of retinal function.
520 $a In chapter 3, the mfERG interocular comparisons did not show an advantage over traditional methods of between group comparisons in adults with diabetes but did show a significant test order effect when sequentially recording two eyes. A follow up study of the order effect was conducted.
520 $a Chapter 4 shows that only after a sufficient duration of diabetes and the appearance of early nonproliferative diabetic retinopathy, is there a spatial association between first order implicit time delays and second order abnormalities of fast adaptation.
520 $a The studies presented in Chapter 5 reveal early indications of focal retinal neuropathy in adolescents, in both type 1 and type 2 diabetes, with as little as one-year diabetes duration. Regional retinal thickness abnormalities are also reported in comparisons between adolescents with type 1, type 2 and no diabetes. Even more alarming, adolescents with type 2 diabetes were found to also present with significant venular enlargement, retinal thinning and elevated body mass index (BMI).
520 $a Collectively, these studies show neural retina dysfunction very early in the progression of diabetes in both adults and adolescents in the absence of vascular lesions. These are the first studies to examine local retinal function (neural) and structure in adolescents with diabetes. Based on these studies, longitudinal studies of the functional, structural and vascular changes in the adolescent diabetic population should be conducted.
590 $a School code: 0028.
650 4 $a Health Sciences, Ophthalmology. $3 1019445
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0381
690 $a 0571
710 2 $a University of California, Berkeley. $3 687832
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0028
790 1 0 $a Adams, Anthony J., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3331552