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Expression and accumulation of immun...

Howard University., Anatomy.

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Expression and accumulation of immune-related molecules in the healthy and diseased eye.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Expression and accumulation of immune-related molecules in the healthy and diseased eye./
Author:	Montalvo, Vanessa.
Description:	113 p.
Notes:	Adviser: Thomas Heinbockel.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3315268
ISBN:	9780549649151

Expression and accumulation of immune-related molecules in the healthy and diseased eye.
Montalvo, Vanessa.

Expression and accumulation of immune-related molecules in the healthy and diseased eye. - 113 p.

Adviser: Thomas Heinbockel.

Thesis (Ph.D.)--Howard University, 2008.

There are many causes for vision loss, from genetic mutations to injury and damage to old age. The pathogenesis of many eye diseases is still unknown, making it difficult to develop treatments that can help recover or protect the vision of those suffering from eye diseases or who have experienced damage. The goal of this study was to collect information on families of molecules that are expressed in the eye, but are not directly involved in the vision process. Little is known about these molecules and new knowledge about them, in both the healthy and diseased eye, may provide new information about their function in the development and maintenance of the normal eye, as well as changes in their expression due to disease. Information collected here may suggest new leads for treatment and therapy of eye diseases. The families of molecules tested in this study included: (i) constitutively expressed chemokines, (ii) apoptosis-related molecules, (iii) an adaptor molecule, DAP12, and one of its receptors, TREM-2, and (iv) components of the complement system. First, I studied chemokines and apoptosis-related molecules to determine their gene expression at different time points during development and adulthood to evaluate their importance at those time points. Second, I studied an adapter molecule, DAP12, expressed on immune-cells, to determine its expression in the healthy and diseased eye and to study its potential role in an immune-mediated disease experimental autoimmune uveitis (EAU). Third, I studied the accumulation of complement components in eye tissues damaged by different mechanisms to evaluate the complement proteins involvement in different types of damage. Observations of interest include a variety of expression patterns among different families of molecules related to the immune and apoptosis systems at different developmental stages. Thus Bad, Bak, and Bax were more highly expressed during development, while Fas, FasL, and TRAIL were more highly expressed in the adult eye, cells in inflamed eyes that express DAP12 were identified and DAP12 has anti-inflammatory properties in EAU, and complement components accumulate in tissues with certain types of damage and, unexpectedly, even in healthy tissues adjacent to inflammation. Observations made in these studies reveal new features of families of molecules related to immunity and apoptosis that are expressed in the healthy and diseased eye. Furthermore, information collected in these studies could provide new ideas for therapeutic targets of eye disease.

ISBN: 9780549649151Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Expression and accumulation of immune-related molecules in the healthy and diseased eye.
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100 1 $a Montalvo, Vanessa. $3 1025261
245 1 0 $a Expression and accumulation of immune-related molecules in the healthy and diseased eye.
300 $a 113 p.
500 $a Adviser: Thomas Heinbockel.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4103.
502 $a Thesis (Ph.D.)--Howard University, 2008.
520 $a There are many causes for vision loss, from genetic mutations to injury and damage to old age. The pathogenesis of many eye diseases is still unknown, making it difficult to develop treatments that can help recover or protect the vision of those suffering from eye diseases or who have experienced damage. The goal of this study was to collect information on families of molecules that are expressed in the eye, but are not directly involved in the vision process. Little is known about these molecules and new knowledge about them, in both the healthy and diseased eye, may provide new information about their function in the development and maintenance of the normal eye, as well as changes in their expression due to disease. Information collected here may suggest new leads for treatment and therapy of eye diseases. The families of molecules tested in this study included: (i) constitutively expressed chemokines, (ii) apoptosis-related molecules, (iii) an adaptor molecule, DAP12, and one of its receptors, TREM-2, and (iv) components of the complement system. First, I studied chemokines and apoptosis-related molecules to determine their gene expression at different time points during development and adulthood to evaluate their importance at those time points. Second, I studied an adapter molecule, DAP12, expressed on immune-cells, to determine its expression in the healthy and diseased eye and to study its potential role in an immune-mediated disease experimental autoimmune uveitis (EAU). Third, I studied the accumulation of complement components in eye tissues damaged by different mechanisms to evaluate the complement proteins involvement in different types of damage. Observations of interest include a variety of expression patterns among different families of molecules related to the immune and apoptosis systems at different developmental stages. Thus Bad, Bak, and Bax were more highly expressed during development, while Fas, FasL, and TRAIL were more highly expressed in the adult eye, cells in inflamed eyes that express DAP12 were identified and DAP12 has anti-inflammatory properties in EAU, and complement components accumulate in tissues with certain types of damage and, unexpectedly, even in healthy tissues adjacent to inflammation. Observations made in these studies reveal new features of families of molecules related to immunity and apoptosis that are expressed in the healthy and diseased eye. Furthermore, information collected in these studies could provide new ideas for therapeutic targets of eye disease.
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