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Occupational chemical causes of coro...

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Occupational chemical causes of coronary artery disease in aluminum workers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Occupational chemical causes of coronary artery disease in aluminum workers./
Author:	Sircar, Kanta Devi.
Description:	158 p.
Notes:	Director: Stanislav Kasl.
Contained By:	Dissertation Abstracts International65-11B.
Subject:	Health Sciences, Occupational Health and Safety. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3152992
ISBN:	9780496134328

Occupational chemical causes of coronary artery disease in aluminum workers.
Sircar, Kanta Devi.

Occupational chemical causes of coronary artery disease in aluminum workers. - 158 p.

Director: Stanislav Kasl.

Thesis (Ph.D.)--Yale University, 2004.

Conclusion. There was a small but statistically significant association between carbon monoxide and CAD but no association between BSF, BAP, particulates and heat and CAD.

ISBN: 9780496134328Subjects--Topical Terms:

1017799
Health Sciences, Occupational Health and Safety.

Occupational chemical causes of coronary artery disease in aluminum workers.
LDR:02888nam 2200313 a 45 001 858120
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020 $a 9780496134328
035 $a (UMI)AAI3152992
035 $a AAI3152992
040 $a UMI $c UMI
100 1 $a Sircar, Kanta Devi. $3 1025150
245 1 0 $a Occupational chemical causes of coronary artery disease in aluminum workers.
300 $a 158 p.
500 $a Director: Stanislav Kasl.
500 $a Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5666.
502 $a Thesis (Ph.D.)--Yale University, 2004.
520 $a Conclusion. There was a small but statistically significant association between carbon monoxide and CAD but no association between BSF, BAP, particulates and heat and CAD.
520 $a Introduction/rationale. Several occupational exposures that are widespread in the aluminum industry are suspected cardiotoxins. A case-control study nested in a longitudinal cohort study of aluminum workers was performed to examine the association of coronary artery disease (CAD) and four exposures [coal tar pitch volatiles (CTPV), particulates (total and respirable), heat and carbon monoxide], taking into account known CAD risk factors.
520 $a Method. 475 cases of CAD and 11,512 controls were investigated. CAD was defined using ICD-9 codes, 410, 411, 413 or 414. An extensive job dictionary and a job exposure matrix were created to assign exposure to relevant job titles. Cumulative exposure for CTPV [benzene soluble fraction (BSF)], benzo(a)pyrene (BAP), particulates (total and respirable) and carbon monoxide was calculated using qualitative industrial hygiene assessment and quantitative measurements and work history. A heat exposure index score was assigned based on the job at the time of diagnosis of CAD. A matched study design was used to evaluate risk of heat whereby two controls were assigned by the job they held during the same time period.
520 $a Results. The risk of CAD was similar in the cases compared to the controls for: BSF [odd ratio and 95% confidence interval (OR) 0.88 (0.61, 1.26)], BAP [OR 1.07 (0.99, 1.15)], respirable particulates [OR 1.0 (0.99, 1.01)], total particulate [OR 1.00 (0.99, 1.01)] and heat exposure [OR 0.97 (0.81, 1.15)]. Carbon monoxide showed a small but statistically significant increased risk of disease [OR 1.004 (1.001, 1.007)]. When investigated as a categorical variable (some occupational exposure versus no occupational exposure to carbon monoxide), there was a 41% increase in risk of CAD in cases compared to control [OR 1.41 (1.26, 1.72)].
590 $a School code: 0265.
650 4 $a Health Sciences, Occupational Health and Safety. $3 1017799
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0354
690 $a 0573
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 65-11B.
790 $a 0265
790 1 0 $a Kasl, Stanislav, $e advisor
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3152992