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The effects of low-fat diet and exer...

University of Maryland, College Park.

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The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial./
Author:	Camhi, Sarah Michelle.
Description:	188 p.
Notes:	Adviser: Deborah R. Young.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3321975
ISBN:	9780549726388

The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial.
Camhi, Sarah Michelle.

The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial. - 188 p.

Adviser: Deborah R. Young.

Thesis (Ph.D.)--University of Maryland, College Park, 2008.

Background. Low-fat diet (D) and exercise (E) are recommended for reducing cardiovascular disease risk. However, the independent and combined effects of D and E on C-reactive protein (CRP) and metabolic syndrome (MS) are unknown. Purpose. The purpose of this dissertation was to examine the changes in CRP and MS between control (C), D, E and diet plus exercise (D+E). Methods. Men (n=197) and postmenopausal women (n=180) with elevated low-density lipoprotein cholesterol and reduced high-density lipoprotein cholesterol, were randomized into a one-year trial with four groups: C, D, E or D+E (Stefanick et al., 1998). Weight loss was not an intervention focus. This secondary data analysis evaluated stored plasma samples for high-sensitivity CRP. MS prevalence was retrospectively found using the NCEP-ATP III definition. CRP change (DeltaCRP) was examined between intervention groups using ANCOVA. Differences between groups for MS at follow-up were retrospectively investigated using logistic regression. All analyses were stratified by gender and controlled for baseline values, body fat change and other appropriate covariates. Results. In women, DeltaCRP was different between D+E vs. C (-0.7 +/- 0.33 mg/L, p = 0.04) and D+E vs. E (-0.9 +/- 0.32 mg/L, p = 0.004). Women also had a decrease in CRP within D+E (Delta log CRP 0.2 +/- 0.035 mg/L; p = 0.0002). After the intervention, DeltaCRP did not differ for men between or within treatment groups. MS at follow-up was not different between C, D, E or D+E in either men or women. In women with MS, DeltaCRP was different between D+E vs. C (-1.3 +/- 0.43 mg/L; p = 0.006), D+E vs. E (-1.1 +/- 0.44 mg/L; p = 0.02), and D vs. C (-1.2 +/- 0.43 mg/L; p = 0.009). In women with MS, CRP decreased from baseline within D+E (Deltalog CRP 0.2 +/- 0.039 mg/L; p=0.0008). At follow-up, there were no differences between or within groups for DeltaCRP in men with MS, or men without MS and women without MS. Conclusion. D and D+E may be effective treatments for reducing CRP in women with MS. Further studies are needed to replicate results and clarify the influence of gender.

ISBN: 9780549726388Subjects--Topical Terms:

1017816
Biology, Physiology.

The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial.
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100 1 $a Camhi, Sarah Michelle. $3 1023856
245 1 4 $a The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome: Findings from a randomized controlled trial.
300 $a 188 p.
500 $a Adviser: Deborah R. Young.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4118.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2008.
520 $a Background. Low-fat diet (D) and exercise (E) are recommended for reducing cardiovascular disease risk. However, the independent and combined effects of D and E on C-reactive protein (CRP) and metabolic syndrome (MS) are unknown. Purpose. The purpose of this dissertation was to examine the changes in CRP and MS between control (C), D, E and diet plus exercise (D+E). Methods. Men (n=197) and postmenopausal women (n=180) with elevated low-density lipoprotein cholesterol and reduced high-density lipoprotein cholesterol, were randomized into a one-year trial with four groups: C, D, E or D+E (Stefanick et al., 1998). Weight loss was not an intervention focus. This secondary data analysis evaluated stored plasma samples for high-sensitivity CRP. MS prevalence was retrospectively found using the NCEP-ATP III definition. CRP change (DeltaCRP) was examined between intervention groups using ANCOVA. Differences between groups for MS at follow-up were retrospectively investigated using logistic regression. All analyses were stratified by gender and controlled for baseline values, body fat change and other appropriate covariates. Results. In women, DeltaCRP was different between D+E vs. C (-0.7 +/- 0.33 mg/L, p = 0.04) and D+E vs. E (-0.9 +/- 0.32 mg/L, p = 0.004). Women also had a decrease in CRP within D+E (Delta log CRP 0.2 +/- 0.035 mg/L; p = 0.0002). After the intervention, DeltaCRP did not differ for men between or within treatment groups. MS at follow-up was not different between C, D, E or D+E in either men or women. In women with MS, DeltaCRP was different between D+E vs. C (-1.3 +/- 0.43 mg/L; p = 0.006), D+E vs. E (-1.1 +/- 0.44 mg/L; p = 0.02), and D vs. C (-1.2 +/- 0.43 mg/L; p = 0.009). In women with MS, CRP decreased from baseline within D+E (Deltalog CRP 0.2 +/- 0.039 mg/L; p=0.0008). At follow-up, there were no differences between or within groups for DeltaCRP in men with MS, or men without MS and women without MS. Conclusion. D and D+E may be effective treatments for reducing CRP in women with MS. Further studies are needed to replicate results and clarify the influence of gender.
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