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Effects of ingesting branched chain ...

Baylor University., Chemistry and Biochemistry.

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Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise./
Author:	Li, Rui.
Description:	145 p.
Notes:	Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Health Sciences, Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3316044
ISBN:	9780549684213

Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise.
Li, Rui.

Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise. - 145 p.

Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.

Thesis (Ph.D.)--Baylor University, 2008.

Purpose. To determine if co-ingestion of carbohydrate (CHO) with branched-chain amino acids (BCAA) or leucine (Leu) downregulates the myostatin signaling pathway and upregulates the makers of myogenesis to a extent greater than that which resistance exercise elicits alone; to explore a possible mechanism for a CHO-BCAA or CHO-Leu induced the modification of myostatin pathway and the activation of myogenesis. Methods: 31 males (22.5yrs; 81.1kg) were randomly assigned to 1 of 3 groups: CHO-BCAA (maltodextrin 1.5 g/kg/bw, BCAA 120mg/kg/bw), CHO-Leucine (maltodextrin 1.5 g/kg/bw, Leu 60mg/kg/bw) and CHO alone (maltodextrin 1.5 g/kg/bw). A control group ingesting placebo (450 ml Crystal LightRTM) was employed from the previous study using the same study design in the same lab. Subjects performed 4 sets of leg press and leg extension at 80% 1RM to failure. Supplementation was ingested at 3 time points: 30 minutes prior to RE, and immediately pre- and post-RE. Venous blood was sampled at baseline; 30min later, immediate postexercise, 30min post-exercise; 2hr post-exercise, and 6hr post-exercise for serum glucose, insulin, IGF-1, myostatin, myostatin propeptide, follistatin and FLRG. Muscle biopsies were sampled at baseline, and 30min post, 2hr post, and 6hr post-exercise for myostatin, ActRIIB, p21cip, p27kip, myoD, myf-5, myogenin and MRF-4 mRNA expression. Serum variables were expressed in delta values as percent change and analyzed via a 4 (group) x 6 (time points) repeated measures MANOVA. Muscle variables were analyzed as CT ratio for relative mRNA expression via a 4 (group) x 4 (time points) repeated measures MANOVA. Univariate ANOVAs (Bonferroni adjusted) were conducted as follow-up tests to the MANOVA Post-hoc tests of the interaction effects demonstrated in the ANOVA were investigated via an independent sample T-test. Results: CHO-BCAA, CHO-Leu and CHO alone significantly increased blood glucose and serum insulin levels combined with resistance exercise. Either CHO-BCAA or CHO-Leu enhanced serum insulin to a greater extent compared with CHO alone, nonetheless no statistically significance indicated. None of the CHO-BCAA, CHO-Leu or CHO alone, compared with placebo, modified serum IGF-1, myostatin and its inhibitors. Regarding muscle samples, a univariate group x time interaction relative to myogenin mRNA expression indicated that the CHO-Leu group was significantly upregulated at the 6hr post time point in comparison with the Placebo group (p < .05). No group x time interactions were observed for the myostain signaling molecules and other myogenic regulatory factors except myogenin. Summary: CHO-Leu supplementation upregulated the myogenin mRNA expression in conjunction with resistance exercise at 6hr post-exercise. Co-ingestion of BCAA or Leu had no effect on the inhibition of myostatin signaling at pre- and post-translational level.

ISBN: 9780549684213Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise.
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100 1 $a Li, Rui. $3 1023852
245 1 0 $a Effects of ingesting branched chain amino acids and carbohydrate on myostatin signaling and markers of myogenesis in response to a bout of heavy resistance exercise.
300 $a 145 p.
500 $a Advisers: Richard B. Kreider; Darryn S. Willoughby; Rafer S. Lutz.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4098.
502 $a Thesis (Ph.D.)--Baylor University, 2008.
520 $a Purpose. To determine if co-ingestion of carbohydrate (CHO) with branched-chain amino acids (BCAA) or leucine (Leu) downregulates the myostatin signaling pathway and upregulates the makers of myogenesis to a extent greater than that which resistance exercise elicits alone; to explore a possible mechanism for a CHO-BCAA or CHO-Leu induced the modification of myostatin pathway and the activation of myogenesis. Methods: 31 males (22.5yrs; 81.1kg) were randomly assigned to 1 of 3 groups: CHO-BCAA (maltodextrin 1.5 g/kg/bw, BCAA 120mg/kg/bw), CHO-Leucine (maltodextrin 1.5 g/kg/bw, Leu 60mg/kg/bw) and CHO alone (maltodextrin 1.5 g/kg/bw). A control group ingesting placebo (450 ml Crystal LightRTM) was employed from the previous study using the same study design in the same lab. Subjects performed 4 sets of leg press and leg extension at 80% 1RM to failure. Supplementation was ingested at 3 time points: 30 minutes prior to RE, and immediately pre- and post-RE. Venous blood was sampled at baseline; 30min later, immediate postexercise, 30min post-exercise; 2hr post-exercise, and 6hr post-exercise for serum glucose, insulin, IGF-1, myostatin, myostatin propeptide, follistatin and FLRG. Muscle biopsies were sampled at baseline, and 30min post, 2hr post, and 6hr post-exercise for myostatin, ActRIIB, p21cip, p27kip, myoD, myf-5, myogenin and MRF-4 mRNA expression. Serum variables were expressed in delta values as percent change and analyzed via a 4 (group) x 6 (time points) repeated measures MANOVA. Muscle variables were analyzed as CT ratio for relative mRNA expression via a 4 (group) x 4 (time points) repeated measures MANOVA. Univariate ANOVAs (Bonferroni adjusted) were conducted as follow-up tests to the MANOVA Post-hoc tests of the interaction effects demonstrated in the ANOVA were investigated via an independent sample T-test. Results: CHO-BCAA, CHO-Leu and CHO alone significantly increased blood glucose and serum insulin levels combined with resistance exercise. Either CHO-BCAA or CHO-Leu enhanced serum insulin to a greater extent compared with CHO alone, nonetheless no statistically significance indicated. None of the CHO-BCAA, CHO-Leu or CHO alone, compared with placebo, modified serum IGF-1, myostatin and its inhibitors. Regarding muscle samples, a univariate group x time interaction relative to myogenin mRNA expression indicated that the CHO-Leu group was significantly upregulated at the 6hr post time point in comparison with the Placebo group (p < .05). No group x time interactions were observed for the myostain signaling molecules and other myogenic regulatory factors except myogenin. Summary: CHO-Leu supplementation upregulated the myogenin mRNA expression in conjunction with resistance exercise at 6hr post-exercise. Co-ingestion of BCAA or Leu had no effect on the inhibition of myostatin signaling at pre- and post-translational level.
590 $a School code: 0014.
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
710 2 $a Baylor University. $b Chemistry and Biochemistry. $3 1023851
773 0 $t Dissertation Abstracts International $g 69-07B.
790 $a 0014
790 1 0 $a Cooke, Matthew B. $e committee member
790 1 0 $a Ding, Jiahuan $e committee member
790 1 0 $a Greenwood, Mike $e committee member
790 1 0 $a Kreider, Richard B., $e advisor
790 1 0 $a Lutz, Rafer S., $e advisor
790 1 0 $a Willoughby, Darryn S., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3316044