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Self-assembly of silk fibroin under ...

University of Massachusetts Amherst.

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Self-assembly of silk fibroin under osmotic stress.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Self-assembly of silk fibroin under osmotic stress./
Author:	Sohn, Sungkyun.
Description:	142 p.
Notes:	Adviser: Samuel P. Gido.
Contained By:	Dissertation Abstracts International67-11B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3242379
ISBN:	9780542978258

Self-assembly of silk fibroin under osmotic stress.
Sohn, Sungkyun.

Self-assembly of silk fibroin under osmotic stress. - 142 p.

Adviser: Samuel P. Gido.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2006.

The supramolecular self-assembly behavior of silk fibroin was investigated using osmotic stress technique. In Chapter 2, a ternary phase diagram of water-silk-LiBr was constructed based on X-ray results on the osmotically stressed regenerated silk fibroin of Bombyx mori silkworm. Microscopic data indicated that silk I is a hydrated structure and a rough estimate of the number of water molecules lost by the structure upon converting from silk I to silk II has been made, and found to be about 2.2 per [GAGAGS] hexapeptide.

ISBN: 9780542978258Subjects--Topical Terms:

1019105
Biophysics, General.

Self-assembly of silk fibroin under osmotic stress.
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020 $a 9780542978258
035 $a (UMI)AAI3242379
035 $a AAI3242379
040 $a UMI $c UMI
100 1 $a Sohn, Sungkyun. $3 1023771
245 1 0 $a Self-assembly of silk fibroin under osmotic stress.
300 $a 142 p.
500 $a Adviser: Samuel P. Gido.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6432.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2006.
520 $a The supramolecular self-assembly behavior of silk fibroin was investigated using osmotic stress technique. In Chapter 2, a ternary phase diagram of water-silk-LiBr was constructed based on X-ray results on the osmotically stressed regenerated silk fibroin of Bombyx mori silkworm. Microscopic data indicated that silk I is a hydrated structure and a rough estimate of the number of water molecules lost by the structure upon converting from silk I to silk II has been made, and found to be about 2.2 per [GAGAGS] hexapeptide.
520 $a In Chapter 3, wet-spinning of osmotically stressed, regenerated silk fibroin was performed, based on the prediction that the enhanced control over structure and phase behavior using osmotic stress method helps improve the physical properties of wet-spun regenerated silk fibroin fibers. The osmotic stress was applied in order to pre-structure the regenerated silk fibroin molecule from its original random coil state to more oriented state, manipulating the phase of the silk solution in the phase diagram before the start of spinning. Monofilament fiber with a diameter of 20 microm was produced.
520 $a In Chapter 4, we investigated if there is a noticeable synergistic osmotic pressure increase between co-existing polymeric osmolyte and salt when extremely highly concentrated salt molecules are present both at sample subphase and stressing subphase, as is the case of silk fibroin self-assembly. The equilibration method that measures osmotic pressure relative to a reference with known osmotic pressure was introduced. Osmotic pressure of aqueous LiBr solution up to 2.75M was measured and it was found that the synergistic effect was insignificant up to this salt concentration. Solution parameters of stressing solutions and Arrhenius kinetics based on time-temperature relationship for the equilibration process were derived as well.
520 $a In Chapter 5, self-assembly behavior of natural silk fibroin within the gland of Bombyx mori silkworm was investigated using osmotic stress technique. Microscopic and thermodynamic details of this self-assembly process along the spinline have been assessed. Formation of a needle-shaped molecular lath under appropriate osmotic stress was found. Silk I degree of hydration of silk gland was quantitatively estimated by image analysis of optical micrographs and the numbers varied from 2.2 to 2.7 depending on the region in the gland. Osmotic pressure in the gland was also estimated by equilibration method.
590 $a School code: 0118.
650 4 $a Biophysics, General. $3 1019105
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0495
690 $a 0786
690 $a 0794
710 2 $a University of Massachusetts Amherst. $3 1019433
773 0 $t Dissertation Abstracts International $g 67-11B.
790 $a 0118
790 1 0 $a Gido, Samuel P., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3242379