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Sarcolemmal repair and recovery from...

University of Maryland, Baltimore., Physical Therapy.

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Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury./
Author:	Roche, Joseph A.
Description:	222 p.
Notes:	Adviser: Robert J. Bloch.
Contained By:	Dissertation Abstracts International69-03B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3303961
ISBN:	9780549516101

Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury.
Roche, Joseph A.

Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury. - 222 p.

Adviser: Robert J. Bloch.

Thesis (Ph.D.)--University of Maryland, Baltimore, 2008.

Skeletal muscle injuries from lengthening contractions are common and can lead to varying levels of limitation of function. The goal of my research has been to study the mechanisms that mediate injury and recovery, by examining muscles injured by a few large-strain lengthening contractions (LSI; Large-strain injury), or by numerous small-strain lengthening contractions (SSI; Small-strain injury).

ISBN: 9780549516101Subjects--Topical Terms:

1017816
Biology, Physiology.

Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury.
LDR:03533nam 2200373 a 45 001 856677
005 20100709
008 100709s2008 ||||||||||||||||| ||eng d
020 $a 9780549516101
035 $a (UMI)AAI3303961
035 $a AAI3303961
040 $a UMI $c UMI
100 1 $a Roche, Joseph A. $3 1023519
245 1 0 $a Sarcolemmal repair and recovery from contraction-induced skeletal muscle injury.
300 $a 222 p.
500 $a Adviser: Robert J. Bloch.
500 $a Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1606.
502 $a Thesis (Ph.D.)--University of Maryland, Baltimore, 2008.
520 $a Skeletal muscle injuries from lengthening contractions are common and can lead to varying levels of limitation of function. The goal of my research has been to study the mechanisms that mediate injury and recovery, by examining muscles injured by a few large-strain lengthening contractions (LSI; Large-strain injury), or by numerous small-strain lengthening contractions (SSI; Small-strain injury).
520 $a I studied injury and recovery in the tibialis anterior (TA) muscle of the rat, to test the hypothesis that myogenesis is not necessary for recovery from LSI. I assessed contractile force, sarcolemmal repair and myogenesis, and inhibited activation of myosatellite cells through X-irradiation, to study recovery without myogenesis. After LSI, TA muscles recovered most of their contractile force within 7 days and repaired their sarcolemmae, but did not show significant myogenesis. TA muscles after SSI, recovered over 14 days and did not repair their sarcolemmae, but showed significant myogenesis. Furthermore, X-irradiated TA muscles recovered normally from LSI but not SSI. These data support the hypothesis that recovery from LSI involves sarcolemmal repair but not myogenesis.
520 $a I next studied recovery from LSI and SSI in control mice and in mice lacking the sarcolemmal repair protein, dysferlin, to test the hypothesis that myogenesis can mediate recovery from LSI when membrane repair is impaired. Using methods adapted from those used for rats, I found that control mice recover from LSI and SSI in a manner similar to the rat. Dysferlin-deficient mice recovered from LSI in a manner similar to SSI in the rat, through myogenesis. Dysferlin-deficient muscles were also infiltrated by more inflammatory cells after both LSI and SSI, compared to controls. My results support the hypothesis that myogenesis mediates recovery from LSI when membrane repair is impaired by the absence of dysferlin and suggest that dysferlin may be involved in controlling inflammation after injury.
520 $a I conclude that the predominant mechanism involved in recovery from contraction-induced injuries varies with the nature of the injury and the state of the muscle. These findings provide insight into the mechanisms that underlie injury, and recovery from injury and also provide insight into the pathogenesis of muscle diseases linked to dysferlin.
590 $a School code: 0373.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
690 $a 0382
690 $a 0719
710 2 $a University of Maryland, Baltimore. $b Physical Therapy. $3 1023518
773 0 $t Dissertation Abstracts International $g 69-03B.
790 $a 0373
790 1 0 $a Alon, Gad $e committee member
790 1 0 $a Bloch, Robert J., $e advisor
790 1 0 $a Lovering, Richard M. $e committee member
790 1 0 $a Randall, William R. $e committee member
790 1 0 $a Russ, David W. $e committee member
790 1 0 $a Ward, Christopher W. $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3303961