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Modulation of the cannabinoid CB1 an...

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Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders./
Author:	Zhang, Ming.
Description:	180 p.
Notes:	Adviser: Ronald F. Tuma.
Contained By:	Dissertation Abstracts International69-01B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3300388
ISBN:	9780549447160

Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders.
Zhang, Ming.

Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders. - 180 p.

Adviser: Ronald F. Tuma.

Thesis (Ph.D.)--Temple University, 2008.

Central nervous system (CNS) disorders, such as stroke and multiple sclerosis, not only affect motor and/or sensation function, language and cognition ability but also alter lifestyle and reduce self-supportiveness of patients. Stroke is one of the leading causes of adult disability and remains the third leading cause of death in the United States. Unlike stroke, which mostly happens to older people, patients experience their first episode of multiple sclerosis (MS) during their young or middle age, and most of them continue to show relapsing-remitting symptoms.

ISBN: 9780549447160Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders.
LDR:03362nam 2200313 a 45 001 856638
005 20100709
008 100709s2008 ||||||||||||||||| ||eng d
020 $a 9780549447160
035 $a (UMI)AAI3300388
035 $a AAI3300388
040 $a UMI $c UMI
100 1 $a Zhang, Ming. $3 1023468
245 1 0 $a Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders.
300 $a 180 p.
500 $a Adviser: Ronald F. Tuma.
500 $a Source: Dissertation Abstracts International, Volume: 69-01, Section: B, page: 0154.
502 $a Thesis (Ph.D.)--Temple University, 2008.
520 $a Central nervous system (CNS) disorders, such as stroke and multiple sclerosis, not only affect motor and/or sensation function, language and cognition ability but also alter lifestyle and reduce self-supportiveness of patients. Stroke is one of the leading causes of adult disability and remains the third leading cause of death in the United States. Unlike stroke, which mostly happens to older people, patients experience their first episode of multiple sclerosis (MS) during their young or middle age, and most of them continue to show relapsing-remitting symptoms.
520 $a It is widely reorganized that inflammatory reactions, especially leukocyte extravasations, is a primary contributor to the damage of the CNS during stroke and MS. It has been shown in various studies that interruptions of leukocytes extravasations could exert neuroprotection during both stroke and MS. Cannabinoids, the synthetic analogs of cannabis, have been found recently to have different neuromodulatory properties. There are two cloned cannabinoid receptors, designated CB1 and CB2. The CB1 receptor is primarily expressed in CNS, exhibiting a presynaptic location and playing a prominent role in synaptic neurotransmission. The CB2 receptor is expressed predominantly by cells of the immune system and has been shown to have immunomodulatory properties. The goal of this thesis to investigate if changing the pattern of CB1 and CB2 receptor activation could alter the outcomes resulting from stoke and multiple sclerosis.
520 $a The studies described in this thesis are based on mouse models of middle cerebral artery occlusion/reperfusion (MCAO/R) and experimental autoimmune encephalomyelitis (EAE). The results demonstrated that the CB1 receptor inhibition is protective while CB2 receptor inhibition is detrimental during cerebral ischemic injury in mouse; and selective stimulation of CB2 receptor decreased cerebral infarction which is possibly mediated by inhibition of leukocyte infiltration. The EAE study also showed that the selective CB2 activation attenuated disease progression and remission that is accompanied by decreased inflammatory responses. In conclusion, changing the pattern of CB1 and CB2 activation influenced the outcomes after cerebral ischemic injury; selective activation of CB2 receptors protected the CNS from ischemic and demyelination disorders which are mediated by the attenuation of inflammatory responses.
590 $a School code: 0225.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0317
690 $a 0419
690 $a 0719
710 2 $a Temple University. $3 959342
773 0 $t Dissertation Abstracts International $g 69-01B.
790 $a 0225
790 1 0 $a Tuma, Ronald F., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3300388