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Psychobiological determinants of hyp...

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Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults./
Author:	Chong, Rachel Y.
Description:	114 p.
Notes:	Advisers: Michael J. Klag; Gary S. Wand.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3288442
ISBN:	9780549311775

Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults.
Chong, Rachel Y.

Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults. - 114 p.

Advisers: Michael J. Klag; Gary S. Wand.

Thesis (Ph.D.)--The Johns Hopkins University, 2008.

Introduction. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in important medical and psychiatric disorders. The evidence supports significant genetic and non-genetic contributions to HPA axis activity. The objective of this dissertation is to explore whether a single nucleotide polymorphism in the mu-opioid receptor (MOR) (A118G), subjective anxiety and mood, and race predict HPA axis responses to psychosocial stress.

ISBN: 9780549311775Subjects--Topical Terms:

1017816
Biology, Physiology.

Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults.
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020 $a 9780549311775
035 $a (UMI)AAI3288442
035 $a AAI3288442
040 $a UMI $c UMI
100 1 $a Chong, Rachel Y. $3 1023404
245 1 0 $a Psychobiological determinants of hypothalamic-pituitary-adrenal axis activity in healthy young adults.
300 $a 114 p.
500 $a Advisers: Michael J. Klag; Gary S. Wand.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7281.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2008.
520 $a Introduction. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been implicated in important medical and psychiatric disorders. The evidence supports significant genetic and non-genetic contributions to HPA axis activity. The objective of this dissertation is to explore whether a single nucleotide polymorphism in the mu-opioid receptor (MOR) (A118G), subjective anxiety and mood, and race predict HPA axis responses to psychosocial stress.
520 $a Methods. 157 healthy young adults (mean age 24.7, SD 8.2) were recruited between October 2000 and January 2006 from Baltimore, Maryland. At initial assessment, they completed psychometric tests measuring baseline perceived anxiety and mood. They then completed the Trier Social Stress Test (TSST), which consisted of 5 minutes of public speaking and 5 minutes of mental arithmetic exercises. Three baseline and five post-TSST blood samples for adrenocorticotrophin (ACTH) and cortisol were drawn. ACTH and cortisol responses to naloxone were also measured to assess for association with the A118G MOR polymorphism. Results were analyzed primarily by longitudinal analysis using the generalized estimating equations (GEE) method. Important confounders, such as age, sex, personality, and socioeconomic status (SES), were controlled for as appropriate.
520 $a Results. Among subjects expressing a 118G allele, there was a higher cortisol response to naloxone (P = 0.046), but a lower cortisol response to the TSST (P = 0.044). A118G genotype did not predict ACTH responses. No measures of anxiety and mood were associated with HPA axis responses to the TSST. Whites had 34% greater relative mean cortisol response than blacks (95% CI: 9%-64%, P = 0.005). Of note, whites and blacks did not differ in subjective anxiety or mood response to the TSST. Race did not predict ACTH responses.
520 $a Conclusions. The A118G allele of the MOR gene and race (black versus white) appear to predict cortisol responses to psychosocial stress. However, subjective perception of anxiety and mood do not. Further study is indicated to explain these findings and to test whether they can be extrapolated to other forms of stress.
590 $a School code: 0098.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0573
690 $a 0719
690 $a 0766
710 2 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 68-11B.
790 $a 0098
790 1 0 $a Klag, Michael J., $e advisor
790 1 0 $a Wand, Gary S., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3288442