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The effects of indirubin derivatives...

Clemson University., Biological Sciences.

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The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7./
Author:	Babcock, Abigail Sue.
Description:	140 p.
Notes:	Adviser: Charles D. Rice.
Contained By:	Dissertation Abstracts International69-08B.
Subject:	Biology, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3316297
ISBN:	9780549691037

The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7.
Babcock, Abigail Sue.

The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7. - 140 p.

Adviser: Charles D. Rice.

Thesis (Ph.D.)--Clemson University, 2008.

Indirubin is the active ingredient in the ancient herbal remedy, Danggui Longhui Wan, which is used as an anti-leukemic, anti-inflammatory, and detoxification treatment. Indirubin-3'-monoxime (IO) is the most widely studied of the indirubin derivatives. Most have been shown to inhibit cyclin-dependent kinases and glycogen synthase kinases, triggering cell cycle arrest and apoptosis with different levels of activity depending on the particular structure. These kinases inhibited by indirubin(s) play key roles in cellular proliferation and immune functions, therefore synthetic indirubins may have significant applications as therapeutic agents for cancer, inflammation, and neurological diseases.

ISBN: 9780549691037Subjects--Topical Terms:

1018625
Biology, General.

The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7.
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008 100709s2008 ||||||||||||||||| ||eng d
020 $a 9780549691037
035 $a (UMI)AAI3316297
035 $a AAI3316297
040 $a UMI $c UMI
100 1 $a Babcock, Abigail Sue. $3 1023348
245 1 4 $a The effects of indirubin derivatives on gene expression and cellular functions in the murine cell line, RAW 264.7.
300 $a 140 p.
500 $a Adviser: Charles D. Rice.
500 $a Source: Dissertation Abstracts International, Volume: 69-08, Section: B, page: 4502.
502 $a Thesis (Ph.D.)--Clemson University, 2008.
520 $a Indirubin is the active ingredient in the ancient herbal remedy, Danggui Longhui Wan, which is used as an anti-leukemic, anti-inflammatory, and detoxification treatment. Indirubin-3'-monoxime (IO) is the most widely studied of the indirubin derivatives. Most have been shown to inhibit cyclin-dependent kinases and glycogen synthase kinases, triggering cell cycle arrest and apoptosis with different levels of activity depending on the particular structure. These kinases inhibited by indirubin(s) play key roles in cellular proliferation and immune functions, therefore synthetic indirubins may have significant applications as therapeutic agents for cancer, inflammation, and neurological diseases.
520 $a Indirubin is also a potent aryl hydrocarbon receptor (AhR) agonist. The AhR is a cytosolic protein, which upon ligand binding is translocated to the nucleus and acts as a transcription factor for genes involved in drug metabolism, oxidative stress, and inhibitors of the cell cycle. Known anthropogenic ligands (PCBs, dioxins, PAHs etc.) are mutagenic, carcinogenic, and immunotoxic. In this study, I examined the effects of select indirubins on gene/protein expression profiles, AhR activation, and cellular functions in the mouse macrophage cell line RAW 264.7. Structure activity relationships (SAR) show that different derivatives of indirubin may differentially affect AhR activation, kinase inhibition, and/or other cellular functions, including intracellular killing of bacteria. The ultimate goal was to identify a synthetic indirubin derivative that would be beneficial to cancer and inflammation research without being overtly toxic.
520 $a From this research, Indirubin-3'-(2,3 dihydroxypropyl)-oximether) (E804), and 6-bromoindirubin-3-monoxime (BIO) were shown to be very potent AhR ligands with strong anti-inflammatory properties. This study also shows that E804 has more clinical promise than its more famous counterpart indirubin-3'-monoxime.
590 $a School code: 0050.
650 4 $a Biology, General. $3 1018625
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0306
690 $a 0419
690 $a 0491
710 2 $a Clemson University. $b Biological Sciences. $3 1017887
773 0 $t Dissertation Abstracts International $g 69-08B.
790 $a 0050
790 1 0 $a Larcom, Lyndon L. $e committee member
790 1 0 $a Rice, Charles D., $e advisor
790 1 0 $a Scott, Thomas R. $e committee member
790 1 0 $a Wheeler, Alfred P. $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3316297