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Immune stress and reproduction: Insi...

Michigan State University.

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Immune stress and reproduction: Insights into the role of norepinephrine and GABA.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Immune stress and reproduction: Insights into the role of norepinephrine and GABA./
Author:	Sirivelu-Prabhakar, Madhu.
Description:	198 p.
Notes:	Adviser: Sheba M.J. Mohankumar.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3332015
ISBN:	9780549845201

Immune stress and reproduction: Insights into the role of norepinephrine and GABA.
Sirivelu-Prabhakar, Madhu.

Immune stress and reproduction: Insights into the role of norepinephrine and GABA. - 198 p.

Adviser: Sheba M.J. Mohankumar.

Thesis (Ph.D.)--Michigan State University, 2008.

Immune stress compromises reproduction. The cytokine, interleukin-1beta (IL-1beta, an immune stressor has been has been shown to activate the stress axis and compromise the reproductive axis, resulting in loss of ovulation. The mechanisms behind these effects are still under investigation. The present work addresses the role of stimulatory neurotransmitters like norepinephrine (NE) and inhibitory ones like GABA in mediating IL-1beta's effects on reproduction. We hypothesized that systemic IL-1beta modulates the levels of NE either at the hypothalamus or brainstem and that GABA too might play a role in this phenomenon. The results of these studies revealed important and novel insights into neuroendocrine changes during a systemic immune challenge: (1) IL-1beta decreases NE input at the level of hypothalamus to inhibit LH, which could be reversed by NE precursor, L-dopa; (2) This decrease in NE was accompanied by increase in GABA and GABA-B antagonist could reverse the inhibitory effect of IL-1beta; (3)Simultaneous activation of the stress and reproductive axes in female rats by IL-1beta involves changes in NE levels in hypothalamus; (4)This could be due to changes in IL-1beta signaling at the cell bodies in the brainstem NE neurons. Together these findings provide strong evidence substantiating the role of NE in mediating the effects of a systemic immune challenge on reproduction and opens up exciting future research possibilities.

ISBN: 9780549845201Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Immune stress and reproduction: Insights into the role of norepinephrine and GABA.
LDR:02355nam 2200277 a 45 001 855233
005 20100708
008 100708s2008 ||||||||||||||||| ||eng d
020 $a 9780549845201
035 $a (UMI)AAI3332015
035 $a AAI3332015
040 $a UMI $c UMI
100 1 $a Sirivelu-Prabhakar, Madhu. $3 1021788
245 1 0 $a Immune stress and reproduction: Insights into the role of norepinephrine and GABA.
300 $a 198 p.
500 $a Adviser: Sheba M.J. Mohankumar.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 5855.
502 $a Thesis (Ph.D.)--Michigan State University, 2008.
520 $a Immune stress compromises reproduction. The cytokine, interleukin-1beta (IL-1beta, an immune stressor has been has been shown to activate the stress axis and compromise the reproductive axis, resulting in loss of ovulation. The mechanisms behind these effects are still under investigation. The present work addresses the role of stimulatory neurotransmitters like norepinephrine (NE) and inhibitory ones like GABA in mediating IL-1beta's effects on reproduction. We hypothesized that systemic IL-1beta modulates the levels of NE either at the hypothalamus or brainstem and that GABA too might play a role in this phenomenon. The results of these studies revealed important and novel insights into neuroendocrine changes during a systemic immune challenge: (1) IL-1beta decreases NE input at the level of hypothalamus to inhibit LH, which could be reversed by NE precursor, L-dopa; (2) This decrease in NE was accompanied by increase in GABA and GABA-B antagonist could reverse the inhibitory effect of IL-1beta; (3)Simultaneous activation of the stress and reproductive axes in female rats by IL-1beta involves changes in NE levels in hypothalamus; (4)This could be due to changes in IL-1beta signaling at the cell bodies in the brainstem NE neurons. Together these findings provide strong evidence substantiating the role of NE in mediating the effects of a systemic immune challenge on reproduction and opens up exciting future research possibilities.
590 $a School code: 0128.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0317
690 $a 0433
710 2 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0128
790 1 0 $a Mohankumar, Sheba M.J., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3332015