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Relationship between glaucoma and se...

The University of Arizona., Epidemiology.

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Relationship between glaucoma and selenium levels in plasma and aqueous humor.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Relationship between glaucoma and selenium levels in plasma and aqueous humor./
Author:	Bruhn, Roberta Lea.
Description:	137 p.
Notes:	Adviser: Zhao Chen.
Contained By:	Dissertation Abstracts International69-03B.
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3303978
ISBN:	9780549516453

Relationship between glaucoma and selenium levels in plasma and aqueous humor.
Bruhn, Roberta Lea.

Relationship between glaucoma and selenium levels in plasma and aqueous humor. - 137 p.

Adviser: Zhao Chen.

Thesis (Ph.D.)--The University of Arizona, 2008.

Purpose. To determine the association of plasma and aqueous humor selenium with glaucoma; and to determine those factors influencing biological levels of selenium in patients with glaucoma and cataract.

ISBN: 9780549516453Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Relationship between glaucoma and selenium levels in plasma and aqueous humor.
LDR:03329nam 2200337 a 45 001 855191
005 20100708
008 100708s2008 ||||||||||||||||| ||eng d
020 $a 9780549516453
035 $a (UMI)AAI3303978
035 $a AAI3303978
040 $a UMI $c UMI
100 1 $a Bruhn, Roberta Lea. $3 1021730
245 1 0 $a Relationship between glaucoma and selenium levels in plasma and aqueous humor.
300 $a 137 p.
500 $a Adviser: Zhao Chen.
500 $a Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1543.
502 $a Thesis (Ph.D.)--The University of Arizona, 2008.
520 $a Purpose. To determine the association of plasma and aqueous humor selenium with glaucoma; and to determine those factors influencing biological levels of selenium in patients with glaucoma and cataract.
520 $a Methods. 47 primary open angle glaucoma (POAG) cases and 54 controls were recruited from surgery patients at the University Physician's Ophthalmology Clinic in Tucson, Arizona. Aqueous humor and plasma selenium concentration was determined by high performance liquid chromatography ion channel plasma-mass spectrometry (HPLC ICP-MS). Potential confounders were assessed via questionnaire. Outcome measures included the odds of glaucoma in relation to plasma selenium and aqueous humor selenium. Factors driving plasma and aqueous humor selenium in the study population were determined via linear regression.
520 $a Results. After adjustment for risk factors and multiple outcomes, the odds of glaucoma in the highest tertile of plasma selenium (OR = 13.51; p=.03) and the middle tertile of aqueous humor selenium (OR = 0.05; p=0.02) were significantly associated with glaucoma. Selenium concentration in plasma and aqueous humor was primarily driven by metabolic factors (cancer, DMII, and ARMD).
520 $a Conclusions. Although a causal pathway cannot be inferred from the analysis, it may be prudent to explore these relations in a larger sample in varying areas of geographic selenium distribution. Such information could be helpful in examining a larger study population and comparing biological data. Evaluating a subject's selenium levels over time and in relation to glaucoma onset could also lend pertinent information.
520 $a Driving forces behind selenium concentrations in this population are mainly metabolic in nature. Selenium levels fluctuate in most tissue as it is metabolized by the body. Selenium supplementation is a significant predictor but this effect is small and may be transient as supplementation only temporarily increases selenium pools. It is interesting to note that sex is a significant predictor of aqueous humor selenium but not of plasma selenium. In this model, female sex predicts a decrease in the selenium within the aqueous humor. This point should be explored in future studies that are powered to discern possibly subtle differences that sex plays in relation to selenium concentrations in plasma and aqueous humor and its possible role in glaucoma.
590 $a School code: 0009.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Ophthalmology. $3 1019445
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0381
690 $a 0383
690 $a 0766
710 2 $a The University of Arizona. $b Epidemiology. $3 1020219
773 0 $t Dissertation Abstracts International $g 69-03B.
790 $a 0009
790 1 0 $a Chen, Zhao, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3303978