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Synthesis and characterization of a ...

Loyola University Chicago.

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Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy./
Author:	Zaitoun, Basel M.
Description:	202 p.
Notes:	Adviser: David Crumrine.
Contained By:	Dissertation Abstracts International69-12B.
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3340173
ISBN:	9780549944461

Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy.
Zaitoun, Basel M.

Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy. - 202 p.

Adviser: David Crumrine.

Thesis (Ph.D.)--Loyola University Chicago, 2008.

Cancer is the second leading cause of death in the USA and cancer kills more than half a million people die annually in the United States alone. Photodynamic therapy (PDT) has emerged as a revolutionary medical technology to more safely fight solid tumors. The core of this technique is to administer a photosensitizing drug that can be activated by a specific wavelength of light in the presence of oxygen. PDT efficacy can be enhanced by improved photosensitizing dyes and increasing its selectivity for tumors. This goal can be achieved by synthesizing dye-folic acid complexes. Attempts have been made to covalently connect squaraine dyes to folic acid as a selectivity director. Squaraines are a class of dyes possessing sharp intense absorption bands above 600 nm in the visible red to near infrared region with the molar absorption coefficients in the neighborhood of 150,000-300,000 M-1cm -1.

ISBN: 9780549944461Subjects--Topical Terms:

516206
Chemistry, Organic.

Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy.
LDR:02083nam 2200289 a 45 001 854369
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020 $a 9780549944461
035 $a (UMI)AAI3340173
035 $a AAI3340173
040 $a UMI $c UMI
100 1 $a Zaitoun, Basel M. $3 1020723
245 1 0 $a Synthesis and characterization of a squaraine dye-folate complex for photodynamic therapy.
300 $a 202 p.
500 $a Adviser: David Crumrine.
500 $a Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7525.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 2008.
520 $a Cancer is the second leading cause of death in the USA and cancer kills more than half a million people die annually in the United States alone. Photodynamic therapy (PDT) has emerged as a revolutionary medical technology to more safely fight solid tumors. The core of this technique is to administer a photosensitizing drug that can be activated by a specific wavelength of light in the presence of oxygen. PDT efficacy can be enhanced by improved photosensitizing dyes and increasing its selectivity for tumors. This goal can be achieved by synthesizing dye-folic acid complexes. Attempts have been made to covalently connect squaraine dyes to folic acid as a selectivity director. Squaraines are a class of dyes possessing sharp intense absorption bands above 600 nm in the visible red to near infrared region with the molar absorption coefficients in the neighborhood of 150,000-300,000 M-1cm -1.
520 $a The synthesis of a squaraine dye-folate complex, the characterization of its chemical, biophysical and spectroscopic properties, the investigation of its dark photostability, its cellular uptake and its photoaction in two different cancerous cell lines will be discussed.
590 $a School code: 0112.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, Pharmaceutical. $3 550957
690 $a 0490
690 $a 0491
710 2 $a Loyola University Chicago. $3 1020295
773 0 $t Dissertation Abstracts International $g 69-12B.
790 $a 0112
790 1 0 $a Crumrine, David, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3340173